Hoechst Roussel Pharmaceuticals

Hoechst Marion Roussel

John I White

Richard C Allen

Lawrence L Martin

Grover C Helsley

Brian S Freed

Gerard J O'Malley

R Richard Hamer

This invention relates to N-hydroxy-dibenz�b,e!oxepinalkylamines, N-hydroxy-dibenz�b,e!oxepinalkanoic acid amides and related heterocyclic analogues of the formula ##STR1## where X together with the carbon atoms to which it is attached forms a benzene or thiophene ring; W and Z are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; R.sup.1 is hydrogen, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; R.sup.2 is loweralkyl, cycloalkyl, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; m is 0 or 1 and n is an integer of 0 to 4 or the pharmaceutically acceptable salts thereof. The compounds of this invention are useful as analgesics and topical antiinflammatory agents for the treatment of various dermatoses and agents for the treatment of conditions where accumulation of cyclooxygenase and/or lipoxygenase metabolites is a causative factor.

N-hydroxy-dibenz�b,e!oxepinalkylamines,

N-hydroxy-dibenz �b,e!oxepinalkylamines, N-hydroxy-dibenz

There are disclosed various compounds of the formula below, ##STR1## where X is O, S, NH, N-loweralkyl, or N-arylloweralkyl;

Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related

There are disclosed various compounds of the formula below, ##STR1## where X is O, S, NH, H-loweralkyl, or N-arylloweralkyl;

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Harleysville, PA, United States of America

John I White