Abbott Laboratories Corporation

John Hunter Seely

Edwin Samuel Johnson

John Scott Fairgrieve

Anne Mary Von Esch

Alford M Thomas

Riemond Henry Rippel, Jr

Ronald Lee Gendrich

James Chieh-Hsia Mao

Fortimicin AN is coproduced with fortimicin A, fortimicin B and a number of other minor factors in the fermentation of Micromonospora olivoasterospora ATCC Nos. 21819,31009 or 31010. Structurally, fortimicin AN is 1-N-glycyl-3-O-demethylfortimicin B. The compound is useful as an intermediate for 3-O-demethylfortimicin B which is readily obtained by hydrolysis of fortimicin AN in base.

Method of producing 3-O-demethylfortimicin B from fortimicin AN

Certain phosphonoacetyl aminoacids have been found to be useful antiviral agents suitable to combat herpes virus infection of various types.

Phosphonoacetyl aminoacids

Fortimicin AN is coproduced with fortimicin A, fortimicin B and a number of other minor factors in the fermentation of Micromonospora olivoasterospora ATCC Nos. 21819, 31009 or 31010. Structurally, fortimicin AN is 1-N-glycyl-3-O-demethylfortimicin B. The compound is useful as an intermediate for 3-O-demethylfortimicin B which is readily obtained by hydrolysis of fortimicin AN in base.

Fortimicin AN

A method of treating herpes simplex infections in warm-blooded animals by administering to said animals a carboxylic ester of phosphonoacetic acid of the formula ##STR1## wherein R is a C.sub.1 -C.sub.2 alkyl.

Treatment of herpes simplex infections

Certain nonapeptide amides were found which, upon administration at daily dosages of from about 1-200 .mu.g/kg to warm-blooded animals, cause regression of DMBA-inducible or mammary tumors without causing adverse effects on healthy tissues.

Treatment of a mammary or DMBA inducible tumor

An unnatural nonapeptide with improved biological activities surpassing those of the natural follicle-stimulating lutenizing hormone-releasing hormone (Gn--RH) is described. The new peptide induces ovulation in warm-blooded animals at an oral dose of 5-100 .mu.g./kg.

[Des-gly].sup.10 -GnRH nonapeptide anide analogs in position 6 having

A series of nonapeptide amides has been found which, upon administration at daily dosages of from about 1-200 .mu.g/kg to warm-blooded animals, cause regression and subsequent elimination of certain tumors without causing adverse effects on healthy tissues.

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Lake Forest, IL, United States of America

John Hunter Seely