Omeros Corporation

John Hohmann

George A Gaitanaris

John E Bergmann

Hongkui Zeng

Gregory A Demopulos

Patrick W Gray

Neil S Cutshall

Linda Madisen

Vincent A Florio

Rene Onrust

Fusheng Li

Alexander Gragerov

Kellie L McIlwain

Maria N Pavlova

Demetri Vassilatis

The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.

G protein coupled receptor 85 and SREB3 knockout mice and uses thereof

A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

Use of PDE7 inhibitors for the treatment of movement disorders

Method of identifying a compound for the treatment or prevention of obesity

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Seattle, WA, United States of America

John Hohmann