Embrex, Inc.

Pneuma Respiratory, Inc.

Ochoa Optics LLC

Google Inc.

Zoetis Services LLC

Other

Eyenovia, Inc.

Zarbana Digital Fund LLC

World Theatre, Inc.

Corinthian Ophthalmic, Inc.

Pfizer Corporation

Ah USA 42 LLC

John Hilbert Hebrank

Charles Eric Hunter

Bernard L Ballou, Jr

Louis Thomas Germinario

Kelly C Sparks

Christopher W Maurer

Chengjie Li

Robert D Summer

James J Fallon

Jack C Hunter

Laurie McNeil

Joshua Richard Brown

Mark Packer

Jurgen Klaus Vollrath

Troy Elliott

Patricia V Phelps

J Sid Clements

Thomas E Bryan

James Thornhill Leath

B Alan Chalker, Ii

Thomas J Lindner

Bradley G Johnson

Nathan R Faulks

Johnny Mark Townsend

Arthur Henry Tew

Benjamin Charles McDow

Jonathan Robertson

Stephen P Wolfe

Edward Atkinson Pomeroy, Iii

Tsontcho Ianchulev

Paul Archie Steen

Michael Glenn Schnupper

Daniel Scott Rees

Edward W Gross

Sean Bryan

Nandini Mendu

Robert L Ilich

Judson Sidney Clements

Phillip E Russell

Walter M Fierson

Daniel T DePauw

Thomas P Stern

William Hayes Ferrell, Iii

Tsontcho Inachulev

Phillip L Rybarczyk, Jr

Dan Rees

Jamie Sprenkel

Mike Schnupper

Brantley Angell

Dipak Mahato

William Douglas Samson

Daniel Lee Kennedy

Daniel De Pauw

Paul Brandford

Molly Bland

Monika Garrell

William Hayes Ferrel, Iii

Ollin B Sykes

B Alan Ii Chalker

William H Iii Ferrell

Sean M Bryan

Willian H Iii Ferrell

Alan B Ii Chalker

Benjamin C Mcdow

Edward Atkinson Iii Pomeroy

Brian H Thomas

Edward Atkinson Pomeroy

William H Ferrell

B Alan Chalker

Molly M Bland

Bernard L Ballou

An electronically actuated droplet delivery device includes a housing with an airflow exit at a mouthpiece and an airflow entrance in fluid communication with the airflow exit via an airflow channel. An aperture plate coupled to an electronic actuator energized by a power source produces a droplet plume from a fluid reservoir in fluid communication with the aperture plate. A change of airflow trajectory in the airflow channel and/or a fan provides inertial filtering and removal of droplets in the plume that have a mass mean aerodynamic diameter greater than 5 μm.

Droplet device with inertial filtering

A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities.

Nasal drug delivery apparatus and methods of use

A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.

Drop generating device

A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 &#x3bc;m, so as to target the pulmonary system of the user. The small volume drug ampoule may include a reservoir which comprises an internal flexible membrane separating two internal volumes, a first background pressure fluid volume and a second drug volume.

Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use

An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 &#x3bc;m, so as to target the pulmonary system of the user. the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g., along the airflow path) so as to form a small, hand-held device.

Electronic breath actuated in-line droplet delivery device and methods of use

A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 &#x3bc;m, so as to target the pulmonary system of the user.

Dry powder delivery device and methods of use

A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities is disclosed. The droplet delivery device includes a housing, a nosepiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically actuated by the user when the differential pressure sensor senses a predetermined pressure change within the nosepiece. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter of greater than about 6 microns, preferably greater than about 10 micron, so as to target the nasal passageways and sinus cavities of the user.

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 &#x3bc;m, so as to target the pulmonary system of the user.

Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device

Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device

Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency

Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment

A method for disseminating emergency notification content from an emergency originating source. The method comprising: delivering the emergency notification content from the emergency originating source to at least one transmitting party; selecting a subset of users from among a set of users for dissemination of the emergency notification content based on the subject matter of the emergency notification content; and delivering the emergency notification content from the at least one transmitting party to a device corresponding to each user from the selected subset of users.

Remote sensors for detecting alert conditions and notifying a central station

Droplet delivery device for delivery of fluids to the pulmonary system and methods of use

Growing community of inventors

Durham, NC, United States of America

John Hilbert Hebrank