Smithkline Beecham Corporation

Pfizer Corporation

Beecham Group Plc

Other

Pzifer Inc.

John Hargreaves Bateson

George Burton

Stephen C Fell

Desmond John Best

David John Payne

David Richard Witty

Martin Leonard Gilpin

Richard L Elliott

Brian Charles Gasson

George W Burton

Brian Peter Clarke

Stephen Christopher Fell

A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a &bgr;-lactam antibiotic, a therapeutically effective amount of an amino acid derivative or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof.

Pyrrolidine and thiazole derivatives with metallo-beta-lactamase inhibitory properties

Beta-thiopropionyl-amino acid derivatives and their use as

A compound of formula (II) or a salt: ##STR1##

Cephaloporins and homologues

.beta.-thiopropionyl-aminoacid derivatives and their use as

Pyrrolidine and thiazole derivatives with antibacterial and              .

.beta.-Lactam antibiotics of formula (I) or a salt thereof, wherein R.sup.1 is hydrogen, methoxy or formamido; R.sup.2 is an acy group; CO.sub.2 R.sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a readily removable carboxy protecting group; R.sup.4 represents up to four substituents; X is S, SO, SO.sub.2, O or CH.sub.2 ; m is 1 or 2; and n is 0, useful in the treatment of bacterial infec ##STR1##

Cephaloporins and homologues, preparations and pharmaceutical

.beta.-Lactam antibiotics of formula (I) or a salt thereof, wherein R.sup.1 is hydrogen, methoxy or formamido; R.sup.2 is an acyl group; CO.sub.2 R.sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a readily removable carboxy protecting group; R.sup.4 represents up to four substituents; X is S, SO, SO.sub.2, O or CH.sub.2 ; m is 1 or 2; and n is 0, useful in the treatment of bacterial infections. ##STR1##

Cephalosporins and homologues, preparations and pharmaceutical

Alphalosporins and 1-carba-1-dethia cephalosporins

.beta.-Lactam compounds of the formula (Ia) including pharmaceutically acceptable salts and in vivo hydrolysable esters, processes for their preparation and their use as antibiotics: ##STR1## wherein R.sup.1 is hydrogen, methoxy or formamido;

Cephalosporin derivatives

.beta.-Lactam antibiotics of the formula (Ia) or a pharmaceutically acceptable salt or pharmaceutically acceptable in vivo hydrolysable ester thereof are disclosed: ##STR1## wherein R.sup.1 is hydrogen, methoxy or formamido; R.sup.2 is a acyl group, in particular that of an antibacterially active cephalosporin; CO.sub.2 R.sup.6 is carboxy group or a carboxylate anion; R.sup.4 is a butenolide or butanolide ring, optionally substituted by one or two alkyl, dialkylamino, alkoxy, hydroxy or aryl groups, which may be the same or different, or, wherein two adjacent carbon atoms which are available for substitution define the common bond of an aromatic fused bicyclic system; X is S, SO, SO.sub.2, O or CH.sub.2 ; and the dashed line adjacent to R.sup.4 represents an optional double bond. Processes for the preparation of compounds together with intermediates for use therein are disclosed.

Growing community of inventors

Reigate, United Kingdom

John Hargreaves Bateson