Harvard College

Fog Pharmaceuticals, Inc.

Parabilis Medicines, Inc.

John Hanney McGee

Gregory Lawrence Verdine

Gerard Hilinski

So Youn Shim

Paula Cristina Ortet

Matthew Reiser Patton

Ty Matthew Thomson

Raheleh Rezaei Araghi

Yue-Mei Zhang

Mark Joseph Mulvihill

Sebastian Christof Theodor Wahl

The present disclosure provides powerful technologies for the development, production, characterization, and/or use of stapled peptide compositions. Among other things, the present disclosure provides strategies for defining amino acid sequences particularly amenable or useful for stapling, as well as technologies, reagents, and systems for developing, producing, characterizing, and/or using stapled peptides having such amino acid sequences.

Collections of peptides, peptide agents, and methods of use thereof

Among other things, the present disclosure provides technologies for modulating functions of beta-catenin. In some embodiments, the present disclosure provides stapled peptides that interact with beta-catenin. In some embodiments, provided stapled peptides interact with beta-catenin at an Axin-binding site of beta-catenin. In some embodiments, the present disclosure provides compounds, compositions and methods for preventing and/or treating conditions, disorders and diseases that are associated with beta-catenin.

Agents modulating beta-catenin functions and methods thereof

The present invention provides peptides comprising a sequence of X-X-X-X-X-X-XPXXPXXPGXXAXXXXLXXXXXXLXXYLXXXX(SEQ ID NO: 13) wherein the amino acids X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, and Xare as defined herein. The present invention further provides pharmaceutical compositions comprising the peptides and methods of using the peptides for treating proliferative diseases such as cancer which are associated with Ras. Also provided are methods of screening a library of peptide dimers using a peptide dimer display technology.

Ras inhibitory peptides and uses thereof

The present invention provides peptides comprising a sequence of XXXXXXXPXXPXXPGXXAXXXXLXXXXXXLXXYLXXXX(SEQ ID NO: 13) wherein the amino acids X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, X, and Xare as defined herein. The present invention further provides pharmaceutical compositions comprising the peptides and methods of using the peptides for treating proliferative diseases such as cancer which are associated with Ras. Also provided are methods of screening a library of peptide dimers using a peptide dimer display technology.

Growing community of inventors

Somerville, MA, United States of America

John Hanney McGee