Phoenix Molecular Designs

Phoenix Molecular Design

John H Van Drie

Subhash Annedi

Jaipal Reddy Nagireddy

Aarthi Jayanthan

My-my Huynh

Timothy Scott Daynard

Sandra Dunn

Sandra E Dunn

Timothy S Daynard

Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity. Such carboxamide derivatives form bicyclic and tricyclic ring systems and the disease or condition associated with RSK activity in a mammal is cancer.

Carboxamide derivatives useful as rsk inhibitors

Described herein are carboxamide derivatives of Formula (II) that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity: wherein R, R, R, R, R, and n are defined in the specification.

Substituted tetrahydropyrido[3',2&#x2032;:4,5]pyrrolo[1,2-&#x3b1;]pyrazine-2-carboxamides as RSK inhibitors

Substituted tetrahydropyrido[3',2&#x2032;:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors

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North Andover, MA, United States of America

John H Van Drie