University of Iowa Research Foundation

John H Tinker

Max T Baker

Jan A Ruzicka

Use of D2-sevoflurane is disclosed as an inhalational anesthetic. Deuterated sevoflurane possess all of the desirable qualities of sevoflurane as an anesthetic and is metabolized more slowly thereby reducing potentially toxic inorganic fluoride release. More particularly, the compound fluorodideutero methyl 1,1,1,3,3,3-hexafluoropropyl ether is disclosed as well as a method for synthesis.

Deuterated sevoflurane as an inhalational anesthetic

This invention relates to a method of synthesizing 1,1,1,3,3,3-hexafluoroisopropyl ether compounds from the reaction of methoxymalanonitrile with a bromine trifluoride composition.

Process for the synthesis of hexafluoroisopropyl ethers

In the process of using sevoflurane as a rapid anesthetic, breakdown of the anesthetic to harmful compound A is slowed if not stopped altogether by cooling the CO.sub.2 scrubber to temperatures that still allow it to work effectively as scrubber but avoid sevoflurane degradation.

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Iowa City, IA, United States of America

John H Tinker