American Home Products Corporation

Glycomed, Inc.

Pharmagenesis, Inc.

Usv Pharmaceutical Corporation

Other

Onyx Therapeutics, Inc.

University of Florida Research Foundation Inc

Proteolix, Inc.

Ecopharm Corporation

Leland Stanford Junior University

American Home Products Corpooration

Phytohealth Corporation

Chakraborty, Utpal R.

Musser, John H.

John H Musser

Anthony F Kreft, Iii

Dennis Michael Kubrak

Dongcheng Dai

Mark Brian Anderson

Narasinga Rao

Reinhold H Bender

Amedeo A Failli

Falguni Dasgupta

James Albert Nelson

Annette L Banker

Mark Stephen Smyth

Craig M Crews

Guy J Laidig

Uresh Shantilal Shah

Peng Cho Tang

Richard E Brown

Wenling Kao

Craig E Caufield

John P Yardley

Philip Floyd Hughes

Robert L Vogel

Richard E Galardy

Howard Jones

Christopher A Demerson

Dominick Mobilio

John Joseph Naleway

Surendra N Sehgal

Kevin R Holme

Jerauld S Skotnicki

Bernard Loev

John Clifford Chabala

Edwin S Lennox

Daniel E Levy

Ronald T Borchardt

James J Bicksler

John M Fidler

Barry A Bunin

Saeed A Abbas

Thomas W Pattison

Glenn D Rosen

John W Giberson

Jinhua An

Darwin S Asa

Mina A Nashed

Hongwei Yuan

Damian Grobelny

Utpal R Chakraborty

Charles A Sutherland

Gregory Scott Schultz

Kenneth L Kees

Ernest Magnien

You Mao Qi

Cho Tang

Asaad Nematalia

Mujahid L Shaikh

Kevin D Shenk

James M Rinker

William H McGregor

Steven C Gilman

Peggy A Radel

Robert A Mack

Lisa A Marshall

Albert J Molinari

Rensheng Xu

Vasil St Georgiev

Cesario O Tio

Bruce A Steinbaugh

Winifred P Howse

Karen S Leu

Falguni Asgupta

Jing Rong Cui

Fu C Huang

Embodiments disclosed herein disclose a fish brooding and filtration system. The system includes a brooding tank configured to contain water and fish for breeding. The brooding tank is in fluid communication a filtration tank, which is configured to extract nitrites from the water circulating through the system. A pump circulates the water through at least one conduit and an injector that receives a flow of water generated by the pump and draws air into the injector. The injector is further operable to inject a mixture of the drawn air and the water into the brooding tank.

Recirculating fish brooding and filtration system

The teachings provided herein generally relate to the preparation and uses of compositions comprising extracts of. The extracts are prepared fromand can comprise, for example, an acid-modified arabinogalactan protein composition having an arabinose:galactose ratio ranging from about 3.5:1 to about 5.0:1, from about 5% to about 10% rhamnose, from about 15% to about 20% galactose, and from about 10% to about 15% glucose. The compositions can be used in the treatment of idiopathic thrombocytopenic purpura and the formulation of medicaments for such treatments.

[object Object]

The identification of triptolide target molecules is described. Also described are methods of screening triptolide-related compounds for binding to these molecules, including screening for enhanced and/or selective binding, and expression analysis of the target molecules in normal and in diseased tissue.

Identification and screening of triptolide target molecules

Disclosed are compounds based on lactone ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy.

Triptolide lactone ring derivatives as immunomodulators and anticancer agents

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.

Compounds for enzyme inhibition

Disclosed are compounds based on C- and D-ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy.

Triptolide C-ring derivatives as anticancer agents and immune modulators

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsinlike activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.

Methods for extraction, isolation, and purification of therapeutically useful compounds fromare described. Extraction steps employing aqueous base and a hydrocarbon solvent, respectively, are found to increase the efficiency of the process and reduce the amount of material that must be removed by chromatography.

Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful as immunosuppressive, anti-inflammatory and anticancer agents.

Triptolide derivatives for modulation of apoptosis and immunosuppression

Compounds useful as immunosuppressive, anti-inflammatory and anticancer agents and methods of their preparation and use are described. The compounds are analogs or derivatives of triptolide and related compounds, modified at the 5- and/or 6-position relative to the naturally occurring compounds.

Triptolide 5,6-derivatives as immunomodulators and anticancer agents

Growing community of inventors

San Carlos, CA, United States of America

John H Musser