Innomed Technologies, Inc.

John H Joseph

Minh Bui

Rod Peterson

Karen Doyle

Precision low-dose, low-waste syringe configurations have a reduced diameter lumen for dispensing 0.01 ml increments of contents. Plunger and lumen configurations and a needle interface eliminate dead space. Ergonomic attachments improve the control and precision of delivery of syringes. An attachment main body includes a gripping surface to permit a user to engage the attachment and move the attachment main body, and thus the syringe plunger relative to the syringe barrel using sliding movement. Optical enhancement features are provided on the attachment to improve the readability of gradations and plunger position. The attachment may be provided with an assist feature, which may be a traction wheel mounted on the attachment body. An alternative configuration suitable for syringe contents of higher viscosity may include a pair of toothed pinion gears on a wheel and which cooperate with respective toothed racks formed on or fastened to the syringe body.

Precision low-dose, low-waste syringes and ergonomic attachments therefor

Embodiments include formulations and methods for topical administration of sugar alcohol to treat a skin condition such as acne. A formulation can include a moisturizer, an emollient, a sugar alcohol and zinc. The sugar alcohol can be erythritol. The erythritol can be administered with zinc chloride. The erythritol and zinc chloride can be formulated at a molar ratio of about 3:1. The methods can also include administration of a therapeutic amount of a second agent such as benzoyl peroxide or a retinoid.

Topical formulations containing erythritol and methods of treating skin conditions

Methods for using precision low-dose, low-waste syringe configurations, which may have a reduced diameter lumen for dispensing 0.01 ml increments of contents. Methods may employ ergonomic attachments that improve the control and precision of the syringe. An attachment main body includes a gripping surface to permit a user to engage the attachment and move the attachment main body, and thus the syringe plunger relative to the syringe barrel using sliding movement. Methods may employ an assist feature on the attachment, which may be a traction wheel. Methods for using syringes with contents of higher viscosity may employ a pair of toothed pinion gears on a wheel and which cooperate with respective toothed racks formed on or fastened to the syringe body.

Precision low-dose,low-waste syringes and ergonomic attachments therefor

Collagenase(EN3835) is a proteinase that can hydrolyze the triple-helical region of collagen under physiological conditions. EN3835 targets the collagenase structural matrix at the site of injection and does not require systemic exposure. Embodiments include methods of lysing subdermal and submucosal collagen to treat various conditions such as bladder dysfunction, esophageal stenosis, benign prostatic hyperplasia, tracheal stenosis, subglottic stenosis and scleroderma.

Collagenasefor treatment of bladder dysfunction

Syringe attachments and syringes have particular suitability to the precision dispensing of small amounts of high viscosity materials, such as dermal fillers. Syringes and attachments may include precision position indicators viewed from multiple positions to enable a user to determine plunger position and the amount of dispensed contents with precision. A configuration of the attachment may be slidably secured to a syringe to permit a user to operate the syringe from a lateral position using sliding movement of the thumb and fingers of one hand, for example. This configuration may be particularly suitable for self-administered insulin injections.

Collagenase(EN3835) is a proteinase that can hydrolyze the triple-helical region of collagen under physiological conditions. EN3835 targets the collagenase structural matrix at the site of injection and does not require systemic exposure. Embodiments include methods of lysing subdermal collagen to treat various conditions such as benign prostatic hyperplasia, tracheal stenosis, subglottic stenosis and scleroderma.

Collagenase Clostridium Histolyticum injection therapies

The present invention provides, among other aspects, methods and compositions for treating Bell's Palsy disease in a subject in need thereof, the method comprising: administering a therapeutically effective amount of a composition comprising human intravenous immunoglobulin (IVIG) to a subject. The present invention also provides, methods and composition for treating Bell's Palsy disease in a subject in need thereof, the method comprising: administering a therapeutically effective amount of a composition comprising human IVIG and a steroid. In certain aspects of the present invention the steroid is a cortical steroid, including Prednison.

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Westlake Village, CA, United States of America

John H Joseph