The Upjohn Co.

The Upjohn Manufacturing Company

John H Coats

Howard A Whaley

William C Snyder

John C Greenfield

Lester A Dolak

Fritz Reusser

Oldrich K Sebek

Gary Edward Zurenko

Vedpal S Malik

Malcolm E Bergy

Alma Dietz

Walter T Sokolski

It has been discovered that rubradirin can be used to treat rubradirin-sensitive, methicillin-resistant staphylococcal infections.

Rubradirin treatment of methicillin-resistant staph

Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus. It is also active against Haemophilus influenzae. Thus, antibiotic U-64,815 can be used in various environments to eradicate or control such bacteria.

Biologically pure culture of Streptomyces microspinus NRRL 12524 capable

Composition of matter and process

Novel antibiotic U-61,732 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Saccharopolyspora hirsuta strain 367, NRRL 12045. This antibiotic is active against gram-positive bacteria, for example, Staphylococcus aureus. Also disclosed are the 11-acyl esters of U-61,732. Thus, these compounds can be used in various environments to eradicate or control such bacteria.

Antibiotic composition of matter

A process for preparing the antibiotic U-59,760. The process is a microbiological process using a biologically pure culture of the novel microbe Saccharopolyspora hirsuta strain 367, NRRL 12045. The antibiotic produced by the process is active against various microorganisms, for example, Staphylococcus aureus, Streptococcus pyogenes, and Klebsiella pneumoniae. Thus, antibiotic U-59,760 can be used in various environments to eradicate or control such bacteria.

Saccharopolyspora culture

Process for producing antibiotic using saccharopolyspora

Microbiological process for preparing the antibiotic lincomycin at temperatures ranging from 18.degree. C. to 45.degree. C. using the newly discovered microorganism Streptomyces vellosus. The subject process advantageously results in the preparation of lincomycin without the concomitant production of lincomycin B (4'-depropyl-4'-ethyllincomycin). The absence of lincomycin B production results in increased lincomycin recovery efficiency.

Process for preparing lincomycin

Novel antibiotic U-59,761 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Saccharopolyspora hirsuta strain 367, NRRL 12045. This antibiotic is active against various microorganisms, for example, Staphylococcus aureus, Streptococcus pyogenes, Sarcina lutea, Klebsiella pneumoniae, Mycobacterium avium, and Bacteroides fragilis. Thus, antibiotic U-59,761 can be used in various environments to eradicate or control such bacteria.

Antibiotic and fermentation process of preparing

A novel microbiological process for preparing 4-thiouracil, a known and useful compound. The compound is produced by the controlled fermentation of the new microorganism Streptomyces libani subsp. soldani, NRRL 8173, and its strains W and P having the NRRL designations NRRL 8174 and NRRL 8175, respectively.

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Kalamazoo, MI, United States of America

John H Coats