The United States of America As Represented by the Department of Health

National Institutes of Health, a Component of the US Dept. of Health & Human Services

University of Illinois

The United States of America As Represented by the Secretary of

Other

Brigham Young University

The United States of America As Represented by the Secretary, Department

John H Cardellina, Ii

Michael R Boyd

James Brislin McMahon

Gordon M Cragg

Kirk R Gustafson

Lewis K Pannell

Richard W Fuller

Yoel Kashman

Gerhard Bringmann

Kirk P Manfredi

Doel Soejarto

John A Beutler

John W Blunt

Laurent A Decosterd

Robert J Gulakowski

Duncan Thomas

Johnson Jato

Peter M Blumberg

Paul Alan Cox

Jon C Clardy

Tawnya C McKee

Guido Francois

Ian Parsons

Karen L Erickson

Kenneth M Snader

Yaii F Hallock

Junichi Ishitoya

Deborah Galinis

Nancy A Sharkey

Krik R Gustafson

Owen S Weislow

Ian Parson

The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.

Calanolide and related antiviral compounds, compositions, and uses thereof

Macrocyclic lactones, compositions, and methods of use

Calanolide and related antiviral compounds, compositions, and uses

The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.

Antiretroviral naphthoquinone compounds compositions and uses thereof

Antiviral naphthoquinone compounds, compositions and uses thereof

The present invention provides new antiviral compounds, i.e., michellamines and derivatives and pharmacologically acceptable salts thereof, methods for isolating such antiviral compounds from a plant species of the genus Ancistrocladus, antiviral compositions containing such antiviral compounds, and methods of using such antiviral compounds for treating patients with viral infections. The antiviral compounds of the present invention inhibit the reproduction and cytopathicity of human acquired immunodeficiency viruses.

Process of preparing michellamine compounds

The present invention relates to an antiviral composition and to methods of treating patients with viral infections. The antiviral composition of the present invention comprises prostratin, a phorbol ester derivative, and a pharmaceutically acceptable carrier. The present composition while having antiviral activity does not have substantial tumor promoting activity and does not have other substantial adverse toxicological properties that would preclude its use in antiviral therapy.

Antiviral composition

Calanolide and related antiretroviral compounds, compositions, and uses

Michellamine antiviral agents, compositions, and treatment methods

The present invention provides new antimalarial compounds called korupensamines, korupensamine derivatives, and pharmacologically acceptable salts thereof, methods for isolating such antimalarial korupensamines from the plant Ancistrocladus korupensis, methods for obtaining new korupensamine derivatives, antimalarial compositions containing such antimalarial korupensamines or derivatives thereof or pharmacologically acceptable salts thereof, and methods of using such antimalarial compounds for the prevention of malaria infections or for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.

Antimalarial korupensamines and pharmaceutical compositions and medical

The present invention relates to a new antitumor compound, a method for isolating same from a red alga, antitumor compositions containing same and methods of using same for treating patients with cancer. The compound of the present invention is 6(R)-bromo-3(S)-bromomethyl-7-methyl-2,3,7-trichloro-1-octene.

Antitumor compound, compositions and method of use

Growing community of inventors

Walkersville, MD, United States of America

John H Cardellina, Ii