Photopharmica Limited

Pitney Bowes Inc.

Akzo Nobel N.v.

Boehringer Mannheim Gmbh

Ocg Microelectronic Materials, Inc.

General Electric Company

Nycomed Amersham Plc

Media Chemical Corp.

John Griffiths

Stanley Beames Brown

David Ian Vernon

Kirste Joanne Mellish

Cassandra Claire O'Grady

Judith D Auslander

John Mama

Elli Rauscher

Paulus Pieter De Wit

Erwin W Erdhuisen

Andrea Lucille Bell

Leonard F Dixon

Stephen F Marcotte, Jr

Kevin Lorimer

Rodney J Hurditch

Alan Mosley

Alan L Hamilton

Mark Samuel Briggs

Mark Hyland

Ingrid M O'Connor

Robert L Van Ewyk

Francis Jones

Jack Schofield

Kasali A Bello

Christopher Blackburn

Valerie Millar

Stephen Anthony Gorman

David John Howard Roberts

Richard George Tunstall

Penelope C Myers

Herbert Frank Askew

The present invention relates to a composition which includes a moiety of formula 

Biologically active methylene blue derivatives

Described are compositions and methods effective to improve the security obtainable for red phosphorescent inks printed, such as by ink jet printing. Specially designed polymeric chelating agents are water soluble and have a high chelating efficiency for lanthanide cations and are themselves strongly adsorbed on polymeric substrates, especially paper. The polymeric chelating agents comprise a polymer chain of either general formulae (1) or (2) containing pyridine-N-oxide, quinoline-N-oxide or isoquinoline-N oxide pendent ligand groups A, where m and n are independent integers in the range of from 1 to 10, and the number average molecular weight of the polymers lies in the range from 1&#xd7;10to 5&#xd7;10: In one aspect a polymeric chelate as described is produced in situ in an aqueous ink formulation and is subsequently printed onto a substrate and dried. In another, a substrate is pre-treated with a chelate as described and dried, and then subsequently printed with an aqueous solution of a fluorescent rare earth salt. In both cases, the result is a wet-fast, intensely luminescent print.

Red-luminescent ink jet printing compositions and methods for improved waterfastness

The present invention relates to a method of photodynamic therapy and to a method of inducing a photocytoxic effect which comprises applying to an area to be treated an effective amount of a compound of formula in which R, R, Rand Reach independently is an optionally -substituted linear, branched or cyclic hydrocarbon group, or Rand Rtogether with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring or Rand Rtogether with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring;

A phenothiazinium compound of Formula (I) wherein: 

The present invention relates to a pharmaceutical composition which contains a compound of formula in which R, R, Rand Rare each n-butyl, where Xis a counteranion and P is 1, 2 or 3, together with a pharmaceutically acceptable carrier, excipient or adjuvant.

Phonoselenazinium compounds of Formula (1): and their use in photodynamic therapy (PDT), particularly as anti-infectives, as anti-cancer agents, and as sterilising agents both for direct use and in combination with a polymer, wherein: A and B are each independently selected from: 

Photosensitisers and their uses

A phenothiazinium compound of Formula (I): wherein: in which R' and R&#x2033; each independently is a linear, branched or cyclic hydrocarbon group, or R&#x2032; and R&#x2033; together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring;

A compound for use as a photosensitiser in PDT, in photochemical internalisation in the production of a cancer vaccine or in the diagnosis or detection of medical conditions, the compound having a photosensitising chromophoric system, a sulphonamido functionality and a carboxy functionality. The compounds used in the present invention are photosensitisers in PDT in vivo, and show phototoxic activity in vitro. The compounds are used to treat pre-cancerous conditions, cancer, ophthalmological disease, vascular problems, arteriosclerosis and restenosis and autoimmune diseases, skin diseases and other benign conditions, and for anti-microbial treatments.

Photosensitisers

In accordance with one embodiment of the present invention, a colorant in an ink jet ink formulation is disclosed. The colorant comprises an organic dye chromophore with at least one functional group Y containing one or more primary, secondary or tertiary amino groups, which in the presence of an acid provides a water soluble, cationic ink jet ink colorant with increased water fastness when applied to paper.

Water soluble colorants for ink jet printing

Ink compositions described are suitable for ink jet printing (ink jet inks) and are highly effective for simultaneously imparting visible and fluorescent images. In the preferred forms, both a dark, visible image and a complementary fluorescent image will be visually discernable as well as machine readable to enable efficient hand and automated processing or handling of the objects printed. These results are achieved by ink formulations that moderate the typically occurring phenomenon of quenching while possessing the physical properties necessary for an ink jet ink. In one form, the inks comprise a first colorant comprising at least one fluorescent dye, the fluorescent dye emitting light within a characteristic emission band when excited by fluorescent-exciting radiation; a second colorant having a light absorption band at longer wavelengths than the characteristic emission band of the first colorant, the second colorant comprising a water-soluble polymeric dye of effective molecular configuration to inhibit quenching of fluorescence of said first colorant due to collisional and resonance energy transfer with said second colorant; and an aqueous liquid vehicle comprising water and a water-soluble vehicle in sufficient amounts to achieve an ink viscosity and surface tension effective for application of the ink to a substrate in a predetermined pattern by ink jet printing. The colorants are present in combination in the aqueous ink in amounts effective to cause the ink, when dry, to exhibit a dark color due to the net absorption spectra of the colorants in the visual range and machine-readable or visually-discernable fluorescence when subjected to fluorescent-exciting radiation.

Homogeneous photosensitive optically variable ink compositions for ink jet printing

Dye intermediate and method

A dye composition for use in optical recording media, comprising at least one cyanine dye having an anion selected from the group consisting of thiocyanate, lactate, hypophosphite, tetracyanonickelate, selenocyanate, trifluromethanesulfonate, ferricyanide, 4-hydroxybutyrate, nitrite, 2-(3',5'-dimethyl-2'-hydroxyphenyl)-2H-benztriazole-4-sulfonate, 1,2-napthoquinone-2-diazide-5-sulfonate and picrate and preferably dissolved in ethyl lactate.

Dye composition for optical recording media having selected anions

Disclosed are liquid-crystalline and infrared-sensitive liquid-crystalline polyesters for optical data storage, processes for the preparation of the same, and an apparatus comprising an infrared-sensitive liquid-crystalline polyester. Owing to covalently bonded dye the liquid crystalline polyester is infrared sensitive and high concentrations of dye are obtainable, without having detrimental effects on the properties of the liquid-crystalline polyester. This results in a highly sensitive liquid-crystalline polyester for optical data storage. Infrared dyes which are preferably bonded in liquid-crystalline polyester are croconium, squarilium, azo, and azamethine dyes.

Liquid crystalline and infrared-sensitive liquid-crystalline polyesters

The invention is in the field of intrinsically thermochromic material. We have found that infrared absorbing dyes of the azamethine type have intrinsically thermochromic properties. The use of said dyes as thermochromic material has the advantage that they can be thermally activated by infrared irradiation. Irradiation of such material with a laser causes a color change that can be used in imaging and optical data storage. The thermochromic dyes can be mixed with polymeric material and from the resulting polymer composition films can be made. If the dye contains polymerizable groups, it may be covalently incorporated into the polymer.

Thermochromic infrared dyes

A negative-working, radiation-sensitive composition comprising an admixture in a solvent of:

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Leeds, United Kingdom

John Griffiths