Kythera Biopharmaceuticals, Inc.

Sage Therapeutics, Inc.

Allergan Sales, Inc.

Optmed, Inc.

H.b. Fuller Company

John Gregory Reid

Robert M Moriarty

Roy A Swaringen, Jr

Achampeta Rathan Prasad

Akhila Kumar Sahoo

Bret Berner

Paul Steven Watson

Stephen Jay Kanes

Jian Wang

James J Doherty

Francesco Gerald Salituro

Albert Jean Robichaud

Boyd Lynn Harrison

Gabriel Martinez Botella

Nathaniel E David

Sankar Subramanian

Steven S Pfeiffer

Nadir Ahmeduddin Mahmood

Vijaya Bhasker Gondi

Murugappa Vedachalam

John Knight

Xufeng Sun

Francis McConville

Roy A Swaringen

Nicholas Holman

Achampeta Prasad

Randy Steinbrink

Gabriel Martinezbotella

Roy A Swaringen Jr

Compounds are provided according to Formula (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein A, R, and Rare as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Oxysterols and methods of use thereof

This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.

Crystalline 19-nor C3,3-disubstituted C21-n-pyrazolyl steroid

Process for the production of methylidene malonates and cyanoacrylates employing in-situ formed iminium salts derived from acid halides and/or acid anhydrides and N,N,N',N&#x2032;-tetra hydrocarbyl diaminoalkanes, the acid halides and/or acid anhydrides being present in a molar excess relative to the diaminoalkanes, as co-reactants with select malonic acid esters and cyanoacetates, respectively.

1,1-disubstituted ethylene process

This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and crystalline solid forms and compositions thereof. Also disclosed herein are methods of making crystalline solid forms of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof. 

Crystalline 19-nor C3,3-disubstituted C21-N-pyrazolyl steroid

Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.

Preparation of bile acids and intermediates thereof

Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-&#x3b1;-hydroxysteroids from &#x394;-9,11-ene, 11-keto or 11-hydroxy-&#x3b2;-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.

Methods for the purification of deoxycholic acid

Improved iminium based processes for the production of cyanoacrylates and methylidene malonates wherein the improvement pertains to the presence of acid chlorides and/or acid anhydrides in the reaction mix.

Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-&#x3b1;-hydroxysteroids from &#x394;-9,11-ene, 11-keto or 11-hydroxy-&#x3b2;-steroids. This inversion is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.

Growing community of inventors

Groton, MA, United States of America

John Gregory Reid