Vertex Pharmaceuticals, Inc.

John Gregg Van Alsten

Michael Waldo

Praveen Mudunuri

Kwame Wiredu Nti-Addae

Simon Adam O'Neil

Irina Nikolaevna Kadiyala

Yuegang Zhang

Kathy Stavropoulos

Bin Song

Mark Strohmeier

Mettachit Navamal

Mark Willem Ledeboer

Ales Medek

Yi Shi

Valdas Jurkauskas

Randal Byrn

Steven Jones

Sarah Robertson

Mohammed Asmal

Wanjung Tsai

Dainius Macikenas

Sarah Marie Robertson

Simon Adam O'neil

The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of Rand Ris H orH and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

Co-crystals and pharmaceutical compositions comprising the same

Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1).&#xbd;HO, Form F of HCl salt of Compound (1).3HO, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

Inhibitors of influenza viruses replication

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Framingham, MA, United States of America

John Gregg Van Alsten