Smithkline Beecham Corporation

John George Catalano

David Norman Deaton

Aaron Bayne Miller

Francis Xavier Tavares

Kristjan S Gudmundsson

John Albert Ray

Sharon Davis Boggs

Paul Richard Sebahar

David Gene Barrett

Leah D'Aurora Richardson

Vicente Samano

The present invention relates to compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.

Chemical compounds

Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.

Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss

The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis 

Propylcarbamate derivatives as inhibitors of serine and cysteine proteases

Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors

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Durham, NC, United States of America

John George Catalano