Blue Spark Technologies, Inc.

Blue Spark Innovations, LLC

John Gannon

Matt Ream

Gary R Tucholski

Salvatore Joseph Casadonte

Adam Perer

James M Petras

Sashi Kolli

Ruth Phillips

Frank Feddrix

Continuous temperature monitors can be used to collect frequent temperature data over large periods of time. A machine learning system trained with collected temperature data can be used to predict future temperature data for patients. Such predictions can be clinically beneficial for disease states in which fever can be fatal, particularly for those fevers having fast onset. For example, patients undergoing chimeric antigen receptor T-cell (CAR-T) therapy may suffer fevers caused by cytokine release syndrome (CRS). Accordingly, a continuous temperature monitor is used to collect temperature data from CAR-T patients with high risk of CRS (or like patients with high fever risk), and the collected temperature data processed by a machine learning system to predict the patient's future temperature profiles. Results of analysis of the predicted temperature profiles may then be provided to the patient and/or clinician.

System and method of using body temperature logging patch

An actively-powered temperature data logger patch with wireless data communication includes a first substrate layer, a second substrate layer, a non-adhesive release layer, and an electronics inlay disposed between the first and second substrate layers. The electronics inlay includes a sealed, flexible battery, and a flexible circuit having a temperature sensor. An outer face of the non-adhesive release layer is has release properties. A replaceable adhesive includes a carrier substrate, a structural adhesive coated on a first face and attached to the outer face of the non-adhesive release layer, and a skin-contact approved adhesive coated on a second opposite face. In another example, an auxiliary sleeve having an exterior surface with an adhesive configured to be removably applied to a subject, may partially enclose the temperature data logger patch in an internal compartment.

Body temperature logging patch

An actively-powered temperature data logger patch with wireless data communication includes a sealed, flexible battery configured to provide continuous electrical power, and a flexible circuit including a microprocessor, a temperature sensor configured to sense a temperature of a target subject, a wireless communication transmitter and an antenna. In one example, the temperature sensor is located at a first end of the patch, and the antenna is located at an opposite, second end of the patch. The patch is configured to conform to a curved surface of the target subject and includes an adhesive configured to be removably applied to skin of the patient. An external computing device is capable of receiving communication from the wireless communication transmitter of the patch via an electromagnetic field.

An actively-powered medical system for monitoring a body temperature of a patient includes a temperature data logger patch with wireless data communication includes a sealed, flexible battery comprising a printed electrochemical cell with an anode and a cathode, and a flexible circuit including a microprocessor, a temperature sensor configured to sense a temperature of a target subject, a wireless communication transceiver and an antenna. In one example, the patch is configured to conform to a curved surface of the target subject. In another example, the patch is used in an actively-powered medical system for monitoring a body temperature of a patient, and includes an adhesive configured to be removably applied to skin of the patient. An external computing device is capable of communication with the wireless communication transceiver of the patch via an electromagnetic field.

An actively-powered temperature data logger patch with wireless data communication includes a sealed, flexible battery comprising a printed electrochemical cell with an anode and a cathode, and a flexible circuit including a microprocessor, a temperature sensor configured to sense a temperature of a target subject, a wireless communication transceiver and an antenna. In one example, the flexible battery and flexible circuit are arranged in a covering, stacked arrangement between first and second substrate layers, and the patch configured to conform to a curved surface of the target subject. In another example, the patch is used in an actively-powered medical system for monitoring a body temperature of a patient, and includes an adhesive configured to be removably applied to skin of the patient. An external computing device is capable of two way communication with the wireless communication transceiver of the patch via an electromagnetic field.

An actively-powered temperature data logger patch with wireless data communication includes a sealed, flexible battery comprising a printed electrochemical cell with an anode and a cathode, and a flexible circuit including a microprocessor, a temperature sensor configured to sense a temperature of a target subject, a wireless communication transmitter and an antenna. In one example, the temperature sensor is located at a first end of the patch, and the antenna is located at an opposite, second end of the patch. The patch is configured to conform to a curved surface of the target subject and includes an adhesive configured to be removably applied to skin of the patient. An external computing device is capable of receiving communication from the wireless communication transmitter of the patch via an electromagnetic field.

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Shaker Heights, OH, United States of America

John Gannon