Harvard College

The General Hospital Corporation

The Brigham and Women's Hospital, Inc.

Dana Farber Cancer Institute & T Cell Diagnostics, Inc.

John G Seidman

Jack L Strominger

Michael B Brenner

Stephen H Ip

Anthony Rosenzweig

Michael S Krangel

Christine E Seidman

Hugh Watkins

A method is described for diagnosing individuals as having hypertrophic cardiomyopathy, e.g. familial or sporadic hypertrophic cardiomyopathy. The method provides a useful diagnostic tool which becomes particularly important when testing asymptomatic individuals suspected of having the disease. Symptomatic individuals have a much better chance of being diagnosed properly by a physician. Asymptomatic individuals from families having a history of familial hypertrophic cardiomyopathy may be selectively screened using the method of this invention allowing for a diagnosis prior to the appearance of any symptoms. Individuals having the mutation responsible for the disease may be counseled to take steps which hopefully would prolong their life, i.e. avoid rigorous exercise. The methodology used in the above method also has broad applicability and may be used to detect other disease-associated mutations in DNA obtained from subjects being tested for other disease-associated mutations.

Method for detecting hypertrophic cardiomyophathy associated mutations

The present invention provides purified polypeptides which comprise at least a portion of a .delta. T cell receptor polypeptide, a .gamma. T cell receptor polypeptide, a .gamma., .gamma. T cell receptor complex or a .gamma., .delta. T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided. Additionally, methods for detecting T cells which have within them or on t

Methods for detection of human gamma, .gamma. T cell receptor

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Milton, MA, United States of America

John G Seidman