Merck + Co., Inc.

Other

John G Ondeyka

Otto D Hensens

Anne W Dombrowski

Dan A Ostlind

Deborah L Zink

Sheo B Singh

Jerrold M Liesch

Jon D Polishook

Kevin M Byrne

Gregory L Helms

Joyce A Greene

Richard G Endris

Diane M Vesey

Arlene M Dahl

Gerald F Bills

Robert T Goegelman

Alan D Adams

James Francis Dropinski

Russell B Lingham

A Brian Jones

Eugene L Dulaney

Richard W Burg

Lawrence R Koupal

Carol F Wichmann

Clare E Gutteridge

Aileen Bouffard

Weiguo Lui

Ali Shiafee

Compounds of Formula Iand the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of:

Therapeutic compounds for treating dyslipidemic conditions

Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.

Antiparasitic agents

There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.

An antiviral agent produced by Hypoxylon fragiforme and having the structure: ##STR1## is described. The product has high activity as an HIV protease enzyme inhibitor and is useful in the treatment of diseases in which control of HIV protease activity is desirable.

Antiviral agent

Disclosed is a novel lipophilic macrolide of assigned Formula I: ##STR1## The compound of assigned Formula I is an analog of rapamycin which has activity as an antifungal agent and as an immunosuppressant.

Lipophilic macrolide useful as an immunosuppressant

Paraherquamide is a fungal metabolite isolated from the known fungus Penicillium paraherquei, and from a newly isolated strain of the fungus Penicillium charlesii. Additional compounds are disclosed which are related to paraherquamide and have been isolated from Penicillium charlesii. The compounds are potent antiparasitic agents. Compositions including such compounds as the active ingredient thereof for antiparasitic uses against endo and ecto parasites are also disclosed, as well as process for the preparation of such compounds from the newly isolated fungus.

Derivatives of paraherquamide isolated from a fermentation broth active

There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of sail microorganism L-681,512 under controlled fermentation conditions.

Anti-inflammatory and antidegenerative compounds isolated from L-681,512

Growing community of inventors

Fanwood, NJ, United States of America

John G Ondeyka