University of Rochester

John G Frelinger

Howard J Federoff

Stephen Dewhurst

Mark A Sullivan

William J Bowers

Baek Kim

Joseph D Rosenblatt

John Puskas

Richard A Willis

Thomas G Evans

Khaled A Tolba

Richard K Barth

Chungwen Wei

Thomas J Evans

Peter K Hocknell

Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein.

Protease activated cytokines

The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patients' cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.

Helper virus-free herpesvirus amplicon particles and uses thereof

The non-coding regulatory sequences of the prostate specific antigen (PSA) are described. Non-human transgenic animals are also provided which express human PSA, which is non-naturally occurring in non-human animals.

Prostate specific regulatory nucleic acid sequences and transgenic

Growing community of inventors

Pittsford, NY, United States of America

John G Frelinger