Metaproteomics, LLC

Nature's Sunshine Products, Inc.

Olin Corporation

Bionexus, Ltd.

Cornell Research Foundation Inc.

Paracelsian, Inc.

Metaproteonics, LLC

Metaprotemics, LLC

Ashni Naturaceuticals, Inc.

Dahlberg, Clinton J.

Tripp, Matthew L.

Babish, John G.

John G Babish

Matthew L Tripp

Jeffrey S Bland

Terrence M Howell

Gary K Darland

Daniel O Lukaczer

Robert Lerman

Linda M Pacioretty

DeAnn J Liska

Clinton J Dahlberg

Jeffrey N Davidson

John H Wedig

Wei Gao

Mohan Kaadige

Joseph Ou

Veera Konda

Amy J Hall

Geoffrey D Wheelock

Anu Desai

Joseph Rininger

Sheryl Krig

Xiaolan Kou

Zhe Khang

Padmasree Chigurupati

M Terrence Howell

Joseph Lamb

Sarah Elison

Jan Debenedetto

Michael L Shuler

Mark Fuller

Brian E Johnson

Xinfang Ma

Holly Brabazon

Jay Bhandari

Veera R Konda

Lisa M Sweeney

Goeffrey Wheelock

Sakina El-Tom

Richard A McMillan

M Lisa Lee

Deann J Liska

Linda Pacioretty

A detoxification system can include an effective amount of a probiotic component and a fiber component in combination with a circulation enhancing component, a high-protein meal replacement component, or both. The detoxification system increases urinary heavy metal excretion, decreases a fecal zonulin level, decreases a fecal calprotectin level, decreases a serum lipopolysaccharide binding protein (LBP) level, increases at least one of a salivary nitrite level and a serum arginine level, or a combination thereof in a subject as compared to a baseline level prior to administration of the detoxification system in an effective dosing regimen.

Methods and compositions to enhance metabolic detoxification systems

Compositions comprising apple, grape, green tea, and olive extracts are presented herein. This synergistic formulations apple, grape, green tea, and olive extract are in amounts that provide a greater antioxidant activity or protein kinase modulating activity than provided by an equivalent amount of any one extract or a sum of the extracts. Further presented are methods of regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent. Also presented are methods of making an activity enhancing composition for regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent.

Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations

Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide; an effective amount of a NOS independent source of nitric oxide; and an effective amount of a myeloperoxidase inhibitor; wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting myeloperoxidase activity.

Compositions and methods for acutley raising nitric oxide levels

A weight loss system is presented herein. In one embodiment, the weight loss system that accelerates weight loss in a subject eating a caloric restricted diet with a minimum daily protein intake of about 3 oz. and engaging in daily physical activity equivalent to about 5,000 steps per day is presented. The weight loss system can comprise an effective amount of: an antimicrobial component that includes berberine,and curcumin; fish oil; a probiotic component that includesspp.,spp., andspp.; an antioxidant, phytochemical component that includes apple extract, grape extract, green tea extract, and olive extract; and a vitamin component that includes vitamins A, B, C, D, and E. The weight loss system can stimulate a weight loss of at least 3% more than if not administered to the subject. Further presented herein is a method of facilitating weight loss in a subject and a method of improving the health of a subject participating in a weight loss program.

Methods and compositions to improve weight loss and cardiometabolic health beyond diet and excercise

Phosphodiesterase-4 (PDE4) inhibiting compositions comprising aand an activity enhancer are disclosed and described. Methods and systems for inhibiting PDE4, as well as, dosage forms comprising aextract and an activity enhancer are also disclosed. Additionally disclosed are methods for enhancing the potency or PDE4 inhibitory activity of aextract by addition of an activity enhancer.

Phosphodiesterase-4 inhibiting phytochemical compositions

Described are four, novel supercritical fluid extracts ofseeds containing about 0.01 to about 40% (w/w) thymoquinone that can be produced using commercial-scale quantities ofseeds. These formulations provide antioxidant, thermogenic, anti-inflammatory and other biological activities qualitatively and quantitatively distinct from thymoquinone alone and are useful as dietary supplements or therapeutics for inflammation-related disorders.

[object Object]

A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

Compositions that treat or inhibit pathological conditions associated with inflammatory response

Botanical compounds to modulate kinase activity are disclosed. The compounds and methods disclosed also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively. The compositions contain at least one fraction isolated or derived from hops or

Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response

Disclosed are botanically based compositions and methods useful for the treatment of metabolic syndrome and diabetes type 2. Compositions, kits, and methods are additionally disclosed for means to augment the activity of identified glucose and insulin regulating drugs.

Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes

The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation.

Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines

Growing community of inventors

Brooktondale, NY, United States of America

John G Babish