General Electric Company

Ge Precision Healthcare LLC

Sabic Innovative Plastics IP B.v.

Other

John Frederick Graf

Christopher Michael Puleo

Victoria Eugenia Cotero

Grant Hay

Jeffrey Michael Ashe

Brion Daryl Sarachan

Kevin Patrick Capaldo

Karkala Arun Kumar

Todd Morris Loehr

William Estel Cheetam

Marshall Gordon Jones

Philippe Schottland

Brian Lee Lawrence

Steven Alfred Tysoe

Adel Fawzy Bastawros

Masako Yamada

Ashwit Dias

Emine Elif Gurel

Gheorghe Cojocariu

John Erik Hershey

Theodorus L Hoeks

Hongyi Zhou

James P Barren

Ying Fan

Vidya Pundalik Kamath

Kirk Dennis Wallace

Lakshmi Sireesha Kaanumalle

Nathan D Hoffman

Scott Leslie

Vicki Herzl Watkins

William Estel Cheetham

Anshu Ghosal

Ertugrul Berkcan

Kenneth Brakeley Welles

John Anderson Fergus Ross

James Edward Pickett

Victor Petrovich Ostroverkhov

Xiaolei Shi

Anup Sood

Glen Peter Koste

Eugene George Olczak

Vasile Bogdan Neculaes

Hua Wang

Michael John Gerdes

Zhiyuan Ren

Dennis Joseph Coyle

Nilesh Tralshawala

Sandra F Feldman

Brock Matthew Lape

David Andrew Shoudy

Stanley Young Hobbs

Ramesh Hariharan

Jack Mathew Webster

Jianbo Di

Alexander Isaakovich Shakhnovich

Kevin R Kidder

Donald M Kulich

Bernhard Joseph Scholz

Vijaya K Kuruganti

Philip Matthew Peters

Arthur Joseph Osborn

Sarah Lillian Katz

Elif Gurel

Mary Elizabeth Spilker

Christopher A Coenjarts

Shixiong Zhu

Andrew Joseph Poslinski

David L Hartter

Joseph A Riello, Jr

Jeffrey James Davis

Kevin P Capaldo

Marshall Gorden Jones

The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.

Neuromodulation to target glucose transporter and/or incretin pathways

The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.

Neuromodulation techniques

Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

Neuromodulation techniques for perturbation of physiological systems

The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

Noninvasive tissue displacement control and monitoring for neuromodulation

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

Multi-beam neuromodulation techniques

Identification of regions-of-interest within cell maps is disclosed. In certain embodiments, identification of the regions-of interest is based on the use of biomarkers selected based on nucleic acid sequence data. The nucleic acid sequence data may be acquired for a homogeneous or heterogeneous set of cells present in the respective tissue sample.

Biological data annotation and visualization

Identification of regions-of-interest within cell maps is disclosed. In certain embodiments, identification of the regions-of interest is based on the use of a plurality of biomarkers, which may be used to generate a multiplexed image of a tissue sample. Based on the identified regions, cells may be extracted and localized sequence data may be generated specific to the regions-of-interest.

The present disclosure relates to characterization of biological samples. By way of example, a biological sample may be contacted with a plurality of probes specific for targets in the sample, such as probes for immune markers and segmenting probes. Acquired image data of the sample may be used to segment the images into epithelial and stromal regions to characterize individual cells in the sample based on the binding of the probes. Further, the biological sample may be characterized by a heterogeneity of the characterized cells.

Quantitative in situ characterization of heterogeneity in biological samples

Dynamic linking of pathway maps and cell maps is disclosed in certain embodiments. In such embodiments, the pathway maps are linked to spatially-localized regional nucleic acid data (e.g., sequence data), as opposed to non-spatially selected nucleic acid data. The pathway map and cell map data may be linked so that interactions results in changes or updates to the linked map, such as the selection or highlighting of cells exhibiting pathway map characteristics specified by a user of updating of node values or states to correspond to that of a cell or cells selected by the user.

A calorie estimating device for measuring a calorie content of a food item is provided. The device comprises a holder substrate, a transmitter antenna configured to transmit ultra-wide band (UWB) signals to at least a portion of the food item disposed on a side of the holder substrate, wherein the transmitter antenna comprises a planar antenna, a first receiver antenna configured to receive at least a portion of UWB signals reflected by the food item, wherein the first receiver antenna comprises a planar antenna, and a second receiver antenna configured to receive at least a portion of UWB signals propagated through the food item, wherein the second receiver antenna comprises a planar antenna.

Systems and methods for non-destructively measuring calorie contents of food items

Growing community of inventors

Ballston Lake, NY, United States of America

John Frederick Graf