Adventist Health System/sunbelt, Inc.

Adventis Health System/sunbelt, Inc.

John Francis

Todd Meyer

Ali Amirkhosravi

Liza Robles-Carrillo

Enriqueta Coll

Ali Amirkosravi

Effector-deficient anti-CD32a monoclonal antibodies are encompassed, as are method and uses for treating CD32a-mediated diseases and disorders, including, thrombocytopenia, allergy, hemostatic disorders, immune, inflammatory, and autoimmune disorders.

Effector-deficient anti-CD32a antibodies

Effector-deficient anti-CD32A antibodies

A method for measuring a generation of thrombin in a sample of whole blood as a function of time includes adding to a sample of whole blood a fluorogenic substrate and a thrombin activator to form an activated sample. A conversion product is permitted to form in the activated sample. Fluorescence is measured as a function of time from a fluorescent group that is released during the formation of the conversion product with the use of a fluorescence detector. The fluorescence detector operates in an extended range mode and has an increased sensitivity. Thrombin generation as a function of time can then be calculated from the measured fluorescence as a function of time.

Thrombin generation determination method

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Longwood, FL, United States of America

John Francis