Alverix, Inc.

Hewlett-Packard Company

Other

Avago Technologies General IP (Singapore) Pte. Ltd.

Avago Technologies General IP Pte, Ltd.

John Francis Petrilla

Daniel Bernardo Roitman

Rong Zhou

Michael John Brosnan

Patrick T Petruno

Ian Hardcastle

Bo U Curry

Rene P Helbing

Carol T Schembri

Joseph Pernyeszi

Michael D Walters

Julie Elizabeth Fouquet

Annette Claire Grot

Rene B Helbing

Rudy L Prater

A diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port constructed and arranged to receive a test strip that includes a flow path for a fluid sample, a sample receiving zone couple to the flow path, a label that specifically binds a target analyte, a detection zone coupled to the flow path and comprising a test region exposed for optical inspection and having an immobilized test reagent that specifically binds the target analyte, and at least one reference feature. The reader is operable to obtain light intensity measurements from exposed regions of the test strip when the test strip is loaded in the port. The data analyzer is operable to perform operations including at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.

Diagnostic test system using measurement obtained from reference feature to modify operational parameter of reader

A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.

Multiple analyte detection systems and methods of detecting multiple analytes

In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip includes a test label that specifically binds a target analyte and at least one non-specific-binding label that is free of any specific binding affinity for the target analyte. Systems and methods of reading assay test strips also are described.

Assay test strips with multiple labels and reading same

An assay test strip includes a flow path, a sample receiving zone, a label, a detection zone that includes a region of interest, and at least one position marker. The at least one position marker is aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest. A diagnostic test system includes a reader that obtains light intensity measurement from exposed regions of the test strip, and a data analyzer that performs at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.

Methods and systems for calibrating illumination source of diagnostic test system

In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

Lateral flow assay systems and methods

In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.

Assaying test strips having different capture reagents

An eye mask is provided that is defined at least partially in terms of absolute, or non-relative, optical power level values. In essence, the eye mask of the invention is a hybrid of the traditional eye mask in that the eye mask of the invention includes power level values on the optical power axis that are based on the minimum OMA set forth in the applicable standard or data sheet specification rather than on measured power level values obtained from the part being tested. Using the hybrid eye mask of the invention obviates the need to perform at least some of the tests often used to measure transmitter attributes. In addition, using the hybrid eye mask of the invention reduces the possibility that a transmitter may fail the eye mask test even though the transmitter operates satisfactorily.

Method and apparatus for testing transmitters in optical fiber networks

Assay test strips and reading same

Growing community of inventors

Palo Alto, CA, United States of America

John Francis Petrilla