Wyeth Holdings Corporation

Wyeth

American Home Products Corporation (del.)

John Francis DiJoseph

Mark Edward Ruppen

Justin Keith Moran

Andrew George Popplewell

John W Simpson

Nitin Krishnaji Damle

Arthur Kunz

Joseph Thomas Rubino

Nishith Merchant

Eugene Joseph Vidunas

Paul David Robbins

Neera Jain

Lioudmila Tchistiakova

Kimberly Ann Marquette

Puja Sapra

Kiran Khandke

Hans-Peter Gerber

Gerald L Reuter

Ghulam N Mir

Luis E Borella

Kiran Manohar Khandke

John McLean Simpson

Lioudmila Gennadievna Tchistiakova

Arthur Kuntz

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

Calicheamicin derivative-carrier conjugates

Disclosed are anti-5T4 antibody drug conjugates and methods for preparing and using the same.

Antibody-drug conjugates

There are provided gastric cytoprotective exogenously acidified aluminum hydroxide antacid compositions which are formed by acidifying, for example, commercial liquid antacid suspensions containing aluminum hydroxide, antacid powders or solids containing aluminum hydroxide, or aluminum hydroxide gel, to the point where the aluminum hydroxide is solubilized. The solutuions may be formulated into liquid dosage forms or spray dried and formulated into solid dosage forms.

Exogenously acidified antacid compositions having cytoprotective

Growing community of inventors

Woodbridge, NJ, United States of America

John Francis DiJoseph