Advanced Cardiovascular Systems, Inc.

Abbott Cardiovascular Systems, Inc.

Abbott Laboratories Corporation

Advanced Cardiovascular, Inc.

John Francis Boylan

John Arthur Simpson

Brian Lee Pelton

Daniel L Cox

William Joseph Boyle

Scott Jason Huter

Christopher J Tarapata

Zhi Cheng Lin

Keif M Fitzgerald

Wayne E Cornish

Kent C B Stalker

Benjamin C Huter

Orlando M Padilla

John E Papp

Andy Edward Denison

Paul F Muller

Masoud Molaei

Peter J D'Aquanni

Matthew J Gillick

Anuja H Patel

Debashis Dutta

Pamela A Kramer-Brown

Barbara E Stamberg

Chicheng Wang

Samir R Patel

Kevin Martin Magrini

Gregory Waimong Chan

Laura Melton Kalvass

Francisco Sanchez

Mark G Wholey

Carol M Lee

Guide wire devices fabricated from a linear pseudo-elastic Ni&#x2014;Ti alloy and methods for their manufacture. The Ni&#x2014;Ti alloy that includes nickel, titanium, and about 3 atomic % (at %) to about 30 at % niobium (Nb). Cold working the Ni&#x2014;Ti alloy stabilizes the alloy's martensitic phase and yields a linear pseudo-elastic microstructure where reversion to the austenite phase is retarded or altogether blocked. The martensitic phase of cold worked, linear pseudo-elastic Ni&#x2014;Ti&#x2014;Nb alloy has an elastic modulus that is considerably higher than the comparable cold worked, linear pseudoelastic binary Ni&#x2014;Ti alloy. This yields a guide wire device that has better torque response and steerability as compared to cold worked, linear pseudoelastic binary Ni&#x2014;Ti alloy or superelastic binary Ni&#x2014;Ti alloy.

Methods for manufacturing a guide wire utilizing a cold worked nickel-titanium-niobium ternary alloy

Guide wire utilizing a cold worked nickel&#x2014;titanium&#x2014;niobium ternary alloy

An endoprosthesis for treating a bifurcated lumen. The distal end of the endoprosthesis can include at least two wings and at least two troughs so the endoprosthesis can adequately scaffold the ostium of a bifurcated lumen by at least partially straddling the carina of the lumen bifurcation. The distal end of the endoprosthesis can also be configured to have increased expandability to help allow conformity to the anatomy of a bifurcated lumen.

Expandable endoprostheses, systems, and methods for treating a bifurcated lumen

Medical devices that include a Ni&#x2014;Ti ternary alloy and methods for their manufacture. The medical devices described herein include at least one part fabricated from the Ni&#x2014;Ti ternary alloy. In the Ni&#x2014;Ti alloys, the ternary alloying element is selected to be compatible with Ni&#x2014;Ti. Example Ni&#x2014;Ti ternary alloys include nickel (Ni), titanium (Ti), and one or more of tantalum (Ta), hafnium (Hf), vanadium (V), zirconium (Zr), scandium (Sc), or yttrium (Y). By virtue of their compatibility with Ni&#x2014;Ti, additions of the ternary alloying element(s) may substitute for titanium in the Ni&#x2014;Ti phase up to the solubility of the ternary element and the remainder can exist as a second phase whose mechanical properties resemble that of the pure ternary element and whose elastic modulus exceeds that of the Ni&#x2014;Ti matrix.

Medical device utilizing a nickel-titanium ternary alloy having high elastic modulus

Guide wire utilizing a nickel&#x2014;titanium alloy having high elastic modulus in the martensitic phase

A radiopaque nitinol stent for implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element including tungsten. The added tungsten in specified amounts improve the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same strut pattern coated with a thin layer of gold. Furthermore, the nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility.

Thermoelastic and superelastic NI-TI-W alloy

Thermoelastic and superelastic Ni&#x2014;Ti&#x2014;W alloy

There is disclosed medical devices, such as stents, guidewires and embolic filters, comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold. There is also disclosed a radiopaque marker comprising the disclosed binary alloy, as well as medical devices having the radiopaque marker attached thereto. Methods of attaching the radiopaque marker to the medical devices, such as by welding, are also disclosure also disclosed.

Radiopaque markers and medical devices comprising binary alloys of titanium

There is disclosed a radiopaque marker comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold. There is also disclosed various medical devices, such as stents, guidewires and embolic filters, that have the radiopaque marker attached thereto. Methods of attaching the radiopaque marker to the medical devices, such as by welding, are also disclosed.

Radiopaque markers comprising binary alloys of titanium

Thermoelastic and superelastic Ni-Ti-W alloy

A strut assembly to be used in conjunction with an embolic filtering device has varying strut thicknesses, with the thickness selected based at least in part on the flexing characteristics of the particular portion of the strut assembly. The strut assembly is formed with patterns having flexing portions and stable portions, with the flexing portions contributing to the flexibility of the strut assembly during delivery and recovery in the patient's vasculature. The stable portions remain relatively unflexed and stiff when being delivered or recovered from the patient's vasculature. The stable portions provide strength and increased radiopacity to the strut assembly which is needed when the strut assembly is deployed in the body vessel. The flexing portions act much like a mechanical hinges in providing the needed flexibility to resiliently bend when being delivered through tortuous anatomy of the patient.

Variable thickness embolic filtering devices and methods of manufacturing the same

Cold worked nickel-titanium alloys that have linear pseudoelastic behavior without a phase transformation or onset of stress-induced martensite as applied to a medical device having a strut formed body deployed from a sheath. In one application, an embolic protection device that employs a linear pseudoelastic nitinol self-expanding strut assembly with a small profile delivery system for use with interventional procedures. The expandable strut assembly is covered with a filter element and both are compressed into a restraining sheath for delivery to a deployment site downstream and distal to an interventional procedure. Once at the desired site, the restraining sheath is retracted to deploy the embolic protection device, which captures flowing emboli generated during the interventional procedure. Linear pseudoelastic nitinol is used in the medical device as distinct from non-linear pseudoelastic (i.e., superelastic) nitinol.

Heat treatment for cold worked nitinol to impart a shape setting capability without eventually developing stress-induced martensite

An expandable frame for an embolic filtering device used to capture embolic debris in a body lumen. The expandable frame also includes a filtering element. A nickel-titanium alloy is used to form the frame. Due to limited heat treatment, the frame exhibits linear pseudoelasticity when positioned inside the body lumen. The nickel-titanium alloy includes a ternary element such as iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, or hafnium so that the frame is also radiopaque.

Radiopaque nitinol embolic protection frame

Cold worked nickel-titanium alloys that have linear pseudoelastic behavior without a phase transformation or onset of stress-induced martensite as applied to a medical device having a strut formed body deployed from a sheath is disclosed. In one application, an embolic protection device that employs a linear pseudoelastic nitinol self-expanding strut assembly with a small profile delivery system for use with interventional procedures is disclosed. The expandable strut assembly is covered with a filter element and both are compressed into a restraining sheath for delivery to a deployment site downstream and distal to an interventional procedure. Once at the desired site, the restraining sheath is retracted to deploy the embolic protection device, which captures flowing emboli generated during the interventional procedure. Linear pseudoelastic nitinol is used in the medical device as distinct from non-linear pseudoelastic (i.e., superelastic) nitinol.

Devices configured from heat shaped, strain hardened nickel-titanium

A radiopaque nitinol medical device such as a stent for use with or implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element selected from the group of chemical elements consisting of iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, or hafnium. The added ternary element improves the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same and strut pattern coated with a thin layer of gold. The nitinol stent has improved radioplacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility.

Method for providing radiopaque nitinol alloys for medical devices

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Murrieta, CA, United States of America

John Francis Boylan