Genzyme Corporation

John F Traverse

Benjamin M Cohen

William W Leong

Chengmin Zhang

Gregg B Feigelson

Jean Xu

Luis Z Avila

Arthur J Coury

Peter K Jarrett

Stephen D Goodrich

Hildegard M Kramer

Ying Li

Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high ('good' to 'excellent') adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.

Hydrogels for orthopedic repair

Growing community of inventors

Somerville, MA, United States of America

John F Traverse