American Cyanamid Company

John F Poletto

Seymour Bernstein

Martin J Weiss

Karel F Bernady

Robert E Schaub

Ransom B Conrow

Middleton Brawner Floyd

Gerald J Siuta

Middleton B Floyd, Jr

Vijay G Nair

Dennis W Powell

Diane H Boschelli

Ralph G Child

Adolph E Sloboda

Leslie H Sutherland

Substituted quinolinecarboxylic acids useful in the treatment of arthritis by inhibiting the progressive joint deterioration characteristic of arthritic disease and for inducing immunosuppression are disclosed. Methods of synthesis and use of the novel compounds are also disclosed.

Substituted quinolinecarboxylic acids

Substituted 4-quinoline-carboxylic acids useful in the treatment of arthritis and inhibition of progressive joint deterioration are disclosed together with methods of use and synthesis thereof.

2-Phenyl-4-quinoline carboxylic acids

This invention concerns novel compounds useful in compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals and as inhibitors of connective tissue destruction. The compounds of this invention comprise certain [oxalylbis(iminophenylenecarbonylimino)]bis[hydroxynaphthalenesulfonic acids] and salts thereof which may be combined with pharmaceutically acceptable carriers or diluents to be administered in the form of conventional pharmaceutical compositions.

Oxalylamides useful as dental antiplaque agents and inhibitors of

This invention concerns novel compounds useful in compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals and as inhibitors of connective tissue destruction. The compounds of this invention comprise certain [ureylenebis-(phenylenesulfonylimino)]bis[hydroxynaphthalenesulfonic acids] and salts thereof which may be combined with pharmaceutically acceptable carriers or diluents to be administered in the form of conventional pharmaceutical compositions.

Dental antiplaque agents and inhibitors of connective tissue destruction

This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.

Novel hydroxy substituted prostanoic acids, esters, congeners,

Ureylenebis substituted (or unsubstituted) phenylenecarbonyl (or sulfonyl)-imino-1,3,5 or 6-naphthalenetrisulfonic acids and salts thereof, useful as complement inhibitors, the intermediates thereof, and the process of making such intermediates and end products.

Ureylenebis substituted (or unsubstituted) phenylene-carbonyl (or

This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.

Novel 2-substituted-3,4-epoxycyclopentan-1-ones,

Carbalkoxymethyl derivatives of rutin poly(H-)sulfate and salts thereof useful as complement inhibitors.

Carbalkoxymethyl derivatives of rutin poly(H-)sulfate and method of use

Carboxyalkyl derivatives of rutin polyl(H-)sulfate and salts thereof useful as complement inhibitors.

Carboxyalkyl derivatives of rutin poly(H-)sulfate

This invention relates to novel 4-oxy-2-substituted-cyclopent-2-en-1-ones of the following general formula: ##STR1## and the optical antipodes, racemic mixtures, and diastereomeric mixtures thereof wherein p is an integer from 2 to 6, inclusive, and J is hydrogen or an appropriate and compatible blocking group such as tetrahydropyranyl or tri(lower alkyl)silyl. Suitable lower alkyl groups contemplated by the present invention are those having up to four carbon atoms such as methyl, ethyl, isopropyl, tert-butyl, etc.

Halogenated-naphthalenetriyltris(sulfonylimino)-aryl multicarboxylic acids and salts thereof useful as complement inhibitors.

Halogenated-naphthalenetriyltris(sulfonylimino)-aryl multicarboxylic

Halogenated-naphthalenetriyltris(sulfonylimino)-aryl disulfonic acid and salts thereof useful as complement inhibitors.

Halogenated-naphthalenetriyltris(sulfonylimino)-aryl disulfonic acids

This disclosure describes novel 4-oxy-2-substituted-cyclopent-2-en-1-ones useful as intermediates for the preparation of homo and nor prostaglandins of the E.sub.2, E.sub.3 and F series.

Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl (and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.

Ureylene phenylene anionic naphthalenesulfonic acids

Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-subsituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-na phthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.

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Nanuet, NY, United States of America

John F Poletto