University of California

Xoma Corporation

Advanced Tissue Sciences, Inc.

John F Hansbrough

Gail K Naughton

Kenneth E Burhop

Raluan G Soltero

Hemoglobin chemically modified to reduce oxygen affinity and prevent dissociation are administered parenterally during resuscitation to patients suffering from burn shock. Such treatment, reduces base deficit, increases cardiac output and mean arterial blood pressure, and improves survival.

Chemically modified hemoglobin for burn shock resuscitation

The present invention provides keratinocytes supported on a hydrophilic membrane, the composition being useful as a skin graft to effect closure of a wound. The invention also provides methods of preparing a keratinocyte-containing membrane suitable for effecting wound closure. In addition, the invention provides methods of effecting closure of wound comprising contacting the wound with a keratinocyte-containing membrane.

Human keratinocytes supported on a hydrophilic membrane and methods of

The present invention provides methods of preventing or treating conditions associated with burn injuries by administering bactericidal/permeability-increasing (BPI) protein product.

Method of treating conditions associated with burn injuries

The present invention relates to a living skin replacement. In particular, it relates to a biosynthetic dressing material composed of a living stromal tissue prepared from stromal cells such as fibroblasts cultured upon a three-dimensional framework and a transitional covering which acts as an epidermal replacement. Such a living skin replacement provides long-term biologic coverage of full-thickness wound defects. Since human fibroblasts are known to be relatively non-antigenic when transferred to allogeneic hosts, a temporary living skin replacement made up of such cells attached to a transitional covering may replace the use of cadaveric skin allografts for achieving temporary wound closure in cases where the patients lack enough healthy skin for autografts.

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Rancho Santa Fe, CA, United States of America

John F Hansbrough