Northwestern University

Northwestern Memorial Healthcare

John Erik Pandolfino

Neelesh A Patankar

Peter James Kahrilas

John O'Dea

Adrian McHugh

Dustin Allan Carlson

Shashank Acharya

Dustin Carlson

Sourav Halder

Zhiyue Lin

Wenjun Kou

Systems and methods include techniques associated with endoscopic manometry. An inflatable structure may be inserted within a tissue structure and inflated or deflated to induce a physiological response for a patient. In operation, the physiological response may be induced while a patient is sedated, which may decrease physical and/or psychological pain to the patient.

Systems and methods for endoscopic manometry

Flow through tubular organs (e.g., the esophagus) is analyzed based on fluid mechanics analysis of medical images. Using computational fluid dynamics, a reduced-order model is constructed and implemented to predict flow rate and fluid pressure developed inside flexible tubular organs inside the body. As one non-limiting example, the constructed model can be applied to analyze esophageal transport using fluoroscopy image sequences to predict flow rate, pressure, esophagus wall stiffness, and active relaxation.

Analysis tool for performing patient-specific analysis of flows through flexible tubular organs

Described here are systems and methods for four-dimensional manometry, which can include generating and displaying rendering data that simultaneously depict spacetime variations in impedance, pressure, and esophageal luminal morphology. From these data, bolus tracking and esophageal opening and velocity data can be measured and visualized without the need for additional imaging, thereby reducing a subject's exposure to otherwise necessary ionizing radiation.

Four-dimensional manometry

Systems, methods, and apparatus for esophageal panometry are provided. An example method includes capturing measurement data including an area and a pressure of an esophageal body via a measurement device positioned with respect to the esophageal body; generating representations of the exported measurement data; analyzing the measurement data to determine esophageal reactivity based on the area and pressure; assessing esophageal function based on the determined esophageal reactivity; and outputting an indication of esophageal function.

Systems, methods, and apparatus for esophageal panometry

Growing community of inventors

Wilmette, IL, United States of America

John Erik Pandolfino