The Procter Gamble Company

John Erich Oblong

Tomohiro Hakozaki

Donald Lynn Bissett

Kimberly Ann Biedermann

Holly Ann Rovito

Stevan David Jones

John McMillan McIver

Robert Scott Youngquist

David Joseph Eickhoff

Charles Carson Bascom

Sancai Xie

Kevin John Mills

Bin Fang Deyer

John Crist Bierman

Supriya Punyani Bareja

Sara Johnson McPhail

Shannon Christine McArthur

Matthew Clair Ehrman

Jesus Velazquez

Thomas Larry Dawson

Wan Ting Chung

Dissanayake Mudiyanselage Mahathma Bandara Dissanayake

Leo Timothy Ii Laughlin

Disclosed is a method of improving the appearance of skin with a low-pH skin care composition that contains hydroxycinnamic acid (HCA) and a vitamin B3 compound in a synergistic combination.

Method of improving the appearance of skin

A method of identifying or evaluating synergistic combinations of actives such as skin-care actives that improve the metabolism of a cell and provides an advantage over using the actives alone. The method includes contacting cells with test agents, alone and in combination, and determining a response of the cells to the test agent(s), wherein the response corresponds to a change in a metabolic indicator associated with glycolysis and a change in a metabolic indicator associated with oxidative phosphylation.

Method of identifying or evaluating synergistic combinations of actives and compositions containing the same

Low pH cosmetic compositions and methods for improving the appearance of skin. The low pH cosmetic compositions herein include a saccharide and, optionally, one or more additional skin care actives to improve the appearance of skin. The lower pH reduces or even eliminates some of the skin health and appearance drawbacks associated with saccharide induced glycation.

Composition and method for improving the appearance of skin

A skin care product is provided. The skin care product includes a multi-component skin care composition disposed in a multi-chamber container. The multi-component skin care composition includes an aqueous carrier component and a nicotinamide riboside component disposed in separate chambers, which prevents these components from contacting one another prior to use. The aqueous carrier component and the nicotinamide riboside component can be separated from one another by one or more fluid impermeable dividing members and/or activatable elements, which upon activation enable contact between the aqueous carrier component and nicotinamide riboside component.

Multi-component skin care product

A method of identifying or evaluating skin-care actives that improve the metabolism of a skin cell. The method includes contacting cells with a stressor and a test agent and determining a response of the cells to the stressor and test agent, based on the change in metabolic indicators associated with glycolysis and/or oxidative phosphylation. The test agent may be identified as a skin-care active when the oxidative phosphorylation and/or glycolysis response corresponds to an improvement in cellular metabolism.

Method of identifying or evaluating beneficial actives and compositions containing the same

Cosmetic methods and compositions for improving the appearance and barrier function of skin. The methods and compositions utilize a combination of niacinamide and a suitable saccharide at low pH to decrease trans-epidermal water loss in skin, reduce the size of hyperpigmented spots, and improve the appearance of skin better than their high pH counterparts.

Method of treating a skin condition and compositions therefor

Cosmetic compositions for alleviating the signs of photoaged skin containing a substituted azole. Methods for alleviating the signs of photoaged skin that include applying a cosmetic composition comprising substituted azole to a target UV-exposed skin surface. The substituted azole compound present in the cosmetic composition may be 1-phenylimidazole, 4-phenylimidazole or a combination thereof. An effective amount of the cosmetic composition is applied to the target skin surface for a period of time sufficient to alleviate at least one sign of photoaging.

Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin

Methods of improving the appearance of aging skin that include applying a cosmetic composition to a target skin surface having one or more signs of aging. The cosmetic composition includes a substituted azole. In some instances, the substituted azole compound is 1-phenylimidazole, 4-phenylimidazole, or combinations thereof. An effective amount of the cosmetic composition is applied for a period of time sufficient to improve the appearance of at least one sign of aging skin.

Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin

The present invention relates to a topical skin care composition containing a safe and effective amount of a skin care active comprising agmatine, and its salt; a safe and effective amount of a first additional skin care active selected from the group consisting of BHT or BHA, hexamidine, cetyl pyridinium chloride, green tea catechins, phytosterols, ursolic acid, compounds derived from plant extracts, their salts and derivatives; and a dermatologically acceptable carrier for the agmatine composition. The present invention also relates to methods of using such agmatine compositions to regulate hair growth and the condition of mammalian skin. The methods generally comprise the step of topically applying the composition to the skin of a mammal needing such treatment, a safe and effective amount of such compositions.

Inhibition of mammalian hair growth

The present invention relates to a topical skin care composition containing a safe and effective amount of a skin care active comprising agmatine, and its salt; a safe and effective amount of a first additional skin care active selected from the group consisting of BHT or BHA, hexamidine, cetyl pyridinium chloride, green tea catechins, phytosterols, ursolic acid, compounds derived from plant extracts, their salts and derivatives; and a dermatologically acceptable carrier for the agmatine composition. The present invention also relates to methods of using such agmatine compositions to regulate hair growth and the condition of mammalian skin. Said methods generally comprise the step of topically applying the composition to the skin of a mammal needing such treatment, a safe and effective amount of such compositions.

Regulation of mammalian hair growth

The present invention relates to topical compositions comprising a vitamin B,compound which are useful for regulating skin condition, especially for regulating the signs of skin aging.

Methods of regulating skin appearance with vitamin B3 compound

The present invention relates to compositions for preventing or treating skin disorders using vitamin B3 compounds and polycyclic compounds. The present invention also relates to methods for regulating skin condition.

Growing community of inventors

Loveland, OH, United States of America

John Erich Oblong