Cala Health, Inc.

Purdue Research Foundation

Leland Stanford Junior University

Symic Ip, LLC

Symic Holdings, Inc.

Symic Biomedical, Inc.

John Eric Paderi

Alyssa Panitch

Katherine Allison Stuart

Kathryn H Rosenbluth

Scott Delp

Tahel Altman

Vijaykumar Rajasekhar

Kinam Park

Shaili Sharma

Steve Higbee

Brian T Kannard

Ritu Lal

Peter Luke Santa Maria

Abhinav Ramani

Brian Hsueh

Nelda Marie Vazquez-Portalatin

Glenn D Prestwich

Samuel Richard Hamner

Erika Kristine Ross

Jonathan C Bernhard

Vijaykumar (Vijay) Rajasekhar

Julia Chen

Sharmistha Saha

Harsha Kabra

Elvis Ikwa

Rush Lloyd Bartlett Ii

Vijay Rajasekhar

Peter Santa Maria

Katherine Stuart

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and/or microwave. Stimulation can be delivered using an open loop system and/or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

Multi-modal stimulation for treating tremor

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

Devices and methods for controlling tremor

Provided herein are synthetic bioconjugates comprising collagen-binding peptides covalently bound to chemically modified glycan backbones, compositions containing the same, and uses thereof.

Bioconjugates with chemically modified backbones

Provided herein are bioconjugates comprising a backbone and at least one branched or unbranched peptide having at least one collagen-binding unit covalently bonded thereto via a spacer and methods of use thereof.

Synthetic bioconjugates

A method for maintaining and/or increasing body temperature of a patient may involve delivering heat to a first location on a limb of the patient, delivering heat to a second location on the limb, apart from the first location, and applying intermittent compression to a third location on the limb, located between the first location and the second location. A device for maintaining and/or increasing body temperature of a patient may include a sleeve for positioning over at least part of one of the patient's limbs, first and second heat delivery members coupled with the sleeve, and an intermittent compression member coupled with the sleeve between the first and second heat delivery members.

Method and system for regulating core body temperature

This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

Collagen-binding synthetic peptidoglycans, preparation, and methods of use

This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.

Extracellular matrix-binding synthetic peptidoglycans

This invention pertains to the field of hyaluronic acid-binding synthetic peptidoglycans and methods of forming and using the same.

Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use

This invention relates to compositions comprising collagen binding peptides coupled to nanoparticles. The invention also relates to a method of imaging a collagenous matrix using a composition comprising collagen binding peptides coupled to nanoparticles.

Collagen-targeted nanoparticles

Growing community of inventors

West Lafayette, IN, United States of America

John Eric Paderi