Possis Medical, Inc.

University of Minnesota

John Edward Morris

Michael John Bonnette

Cindy M Setum

Debra M Kozak

Steven E Wiesel

Robert C Dutcher

Mark Lynn Jenson

Robert G Dutcher

John Bridgeman

Hieu V Le

Rosemary C Beaupre

William Joseph Drasler

Stephen E Weisel

Peter W Carr

Michael C Flickinger

Michael J Annen

Christopher Dunlap

Colleen M Griffith

Michael J Robichaud

Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

Thrombectomy catheter and system

A single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. Embodiments include an outer catheter assembly common to any mode of usage having a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a flow director are passed and advanced. For use as a rheolytic thrombectomy catheter, thrombus is dislodged, entrained, and broken into pieces by jets and evacuated through the lumen of the guide catheter. For use as a crossflow thrombectomy catheter, a flow director having outflow and inflow orifices is provided.

Single operator exchange fluid jet thrombectomy device

Crossflow thrombectomy catheter and system

A single operator exchange fluid jet thrombectomy method employing a single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. The outer catheter assembly is common to any mode of usage and includes a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a jet emanator and a flow director are passed and advanced. In the method, thrombus is dislodged, entrained, and broken into pieces by fluid jets and evacuated through the lumen of the guide catheter.

Single operator exchange fluid jet thrombectomy method

Flexible microcatheter having regions of different flexibility integrally and strategically placed along and about the length of a one-piece composite catheter tube. Distally the flexible microcatheter exhibits pronounced flexibility with respect to locations or regions of flexibility located proximally for navigation along tortuous vascular paths. Different regions of flexibility are formed by applying resins of different Shore hardness readings either singularly or in combination along and about a braid which overlies an inner resin layer. The encapsulated braid provides resistance to kinking and bending of the flexible microcatheter as well as providing for torque transmission and pushability along the length of the flexible microcatheter.

Flexible microcatheter

A rheolytic thrombectomy catheter and method of using same to remove thrombus from a body vessel or other body cavity. Several embodiments are disclosed. All embodiments include an outer catheter having a lumen and an inner high pressure tube of a size to enable it to be passed through the lumen of the catheter. The distal end of the inner high pressure tube extends beyond the distal end of the catheter and carries a jet cap for directing one or more jets of saline proximally toward the distal end of the catheter. In some embodiments, the catheter has a distally located inwardly directed stationary stop and the inner high pressure tube includes a distally located outwardly directed transitional stop for engaging the inwardly directed stationary stop to thereby position the jet cap at a defined distance from the distal end of the catheter. In other embodiments, a stationary stop is located at the proximal end of the catheter and a transitional stop is carried on the proximal end of the inner high pressure tube. In the embodiments having the stationary and transitional stops located proximally, the inner high pressure tube includes a flow director at its distal end. In use, thrombus is dislodged, entrained, and broken into pieces by the saline jets and evacuated proximally through the lumen of the catheter.

Rheolytic thrombectomy catheter and method of using same

Porous Zirconia particles of specific gravity of 2.5-3.5 g/cm.sup.3 and mean particle sizes of 30-400 .mu.m can be synthesized using oil emulsion methods from colloids and used for protein adsorption in stable expanded beds. Expanded beds of less than 1.0 settled bed height to diameter (approximately 10 ml bed volume) are stable at linear fluid velocities of at least about 100 cm/hour.

Protein adsorption by very dense porous zirconium oxide particles in

A rheolytic thrombectomy catheter and method of using same to remove thrombus from a body vessel or other body cavity. The rheolytic thrombectomy catheter has a first tube with a distal open end and a second tube aligned within the first tube and having a flexible tip assembly. A tapered and flexible tip follows a guidewire within and along tortuous and difficult vasculature paths to the site of thrombus. The flexible tip assembly, includes a soft flexible tip and also includes a hard plastic shell offering structural integrity and rigid alignment between a toroidal loop and an inner body to prevent lever arm distortion and to maintain spray gap alignment for saline jet flow emanating from the toroidal loop. Saline jets dislodge, entrain, and break thrombus into pieces which are evacuated through the dual lumen tube. A construction method is also included for mounting of the toroidal loop within the hard plastic shell and attachment of the soft tapered and flexible tip with sufficient bond strength to function as intended for use.

Flexible tip rheolytic thrombectomy catheter and method of constructing

A surgical device and method for removal of tissue, such as thrombus, from a vessel in the body. The device has a first tube with a distal open end and an inward directed stop and a second tube with an outward directed stop for engaging the inward directed stop and thereby regulating the relationship between a retrograde jet and the distal open end. Thrombus is dislodged, entrained, and broken into pieces which are evacuated through the first tube.

Porous zirconia particles of specific gravity of 2.5-3.5 g/cm.sup.3 and mean particle sizes of 30-400 .mu.m can be synthesized using oil emulsion methods from colloids and used for protein adsorption in stable expanded beds. Expanded beds of less than 1.0 settled bed height to diameter (approximately 10 ml bed volume) are stable at linear fluid velocities of at least about 100 cm/hour.

Growing community of inventors

Minneapolis, MN, United States of America

John Edward Morris