Smithkline Beecham Corporation

Other

Affinium Pharmaceuticals, Inc.

Replidyne, Inc.

John Edward Hodgson

Michael Terence Black

Richard Oakley Nicholas

Michael Arthur Lonetto

Martin M Rosenberg

Judith M Ward

Elizabeth Jane Lawlor

Raymond Winfield Reichard

Julie M Pratt

David Justin Charles Knowles

Martin Karl Russel Burnham

Martin Karl Burnham

David Justin Knowles

Robert King Stodola

Patrick Vernon Warren

Richard Lloyd Warren

Leslie Marie Palmer

Jason Craig Fedon

Christopher Michael Traini

Nicola Gail Wallis

Min Wang

Deborah Dee Jaworski

Anna Lisa Kosmatka

Martin Karl Russell Burnham

Lisa Kathleen Shilling

Christine Marie Debouck

Andrew P Fosberry

Jeffrey L Mooney

James Raymond Brown

Magdalena Zalacain

David John Holmes

David John Payne

Stewart Campbell Pearson

Yi Yi Zhong

Phillip N Zarfos

Daniel Robert Gentry

Alison Frances Chalker

Elizabeth J Lawlor

Robert H Reid

Kenneth H Pearce, Jr

Yi Y Zhong

Michael Terance Black

Owen Jenkins

Jamie M Pratt

Gillian Sarginson

Raymond Winfield Riechard

Simon J Foster

Robert H Reid, Jr

Richard Oakly Nicholas

This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Compounds

The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

tRNA synthetase

The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.

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The invention provides methionyl tRNA synthetase (tRS) enzymes fromand methods of producing such tRS by recombinant techniques. Also provided are methods for utilizing tRS for the protection against infection, particularly bacterial infection, most particularlyinfection.

Methionyl tRNA synthetase polypeptides from Staphylococcus aureus

The invention providesmethionyl tRNA synthetase polypeptides and DNA (RNA) encodingmethionyl tRNA synthetase polypeptides and methods for producing such poypeptides by recombinant techniques. Also provided are methods for utilizingmethionyl tRNA synthetase polypeptides for the protection against infection, particularly bacterial infections.

Polynucleotides encoding methionyl tRNA synthetase from Staphylococcus aureus, related products and methods

The invention provides ftsH polypeptides, polynucleotides encoding ftsH polypeptides and related polynucleotides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic methods for detecting

FtsH from Staphylococcus aureus

The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.

The invention provides Fibronectin Binding Protein polypeptides and DNA (RNA) encoding Fibronectin Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Fibronectin Binding Protein polypeptides to screen for antibacterial compounds.

Fibronectin binding proteins

The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.

Member of ATP dependent protease family, clpL

The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.

ribB

Asparaginyl tRNA synthetase from Staphylococcus Aureus

spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.

Spo-rel

The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Growing community of inventors

Malvern, PA, United States of America

John Edward Hodgson