Senesco Technologies, Inc.

Senesco, Inc.

Agribody Technologies, Inc.

Sensco Technologies, Inc.

John E Thompson

Tzann-Wei Wang

Dongen Lily Lu

Catherine Taylor

Dominic O Cliche

John C Carlson

Richard Narayansingh

Larry Petrov

Charles A Dinarello

Elizabeth Heikkila

John Gerard Flanagan

Adrienne Boone

Bruce C Galton

Richard S Dondero

Katalin A Hudak

Leonid Reznikov

Shelley Culp-Stewart

Michelle Senchyna

Yuwen Hong

Marianne Hopkins

Marianne Kaup

Jerald S Feitelson

Catherine A Taylor

Benjamin Pomerantz

Diane Michelle Senchyna

Dominic Cliché

Wendy Wu

Linda Nowack

Tzann-Wei Michael Wang

Zhenyu Cheng

Zhong Sun

Diana Michelle Senchyna

Elisabeth M Heikkila

Dominic 75 Old Chicopee Drive Cliche

The invention relates to methods of producing a plant with delayed senescence comprising inducing at least one nucleotide deletion, insertion or substitution into at least one copy of a gene encoding deoxyhypusine synthase (DHS) in the plant, wherein the nucleotide deletion, insertion or substitution decreases the activity of DHS encoded by the gene in the plant. The invention also relates to plants produced by the methods and progeny thereof.

Plants with modified deoxyhypusine synthase genes

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.

Inhibition of apoptosis-specific eIF-5A(eIF-5A1&#x2033;) with antisense oligonucleotides and siRNA as anti-inflammatory therapeutics

The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.

Compositions comprising siRNA and plasmids

The present invention relates to unique isoforms of eukaryotic initiation Factor 5A ('eIF-5A'): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase ('DHS'), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.

Isoforms of eIF-5A: senescence-induced eIF5A; wounding-induced eIF-5A; growth eIF-5A; and DHS

The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide. The present invention also relates to a truncated form of eIF-5A1 that is useful for inducing apoptosis and killing of cells, especially cancer cells in a mammal.

Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.

siRNA useful to supress expression of EIF-5A1

Polynucleotides encoding canola DHS and antisense polynucleotides thereof

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro-inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat/prevent sepsis and/or hemorrhagic shock.

Use of apoptosis-specific eIF-5A siRNA to down regulate expression of proinflammatory cytokines to treat sepsis

The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Method for inducing apoptosis using apoptosis-specific EIF5-A

Expression vector encoding apoptosis-specific eIF-5A

The present invention relates to unique isoforms of eukaryotic initiation Factor 5A ('eIF-5A'): senescence-induced eIF-5A; wounding/pathogen induced eIF-5A; stress eIF-5A and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase ('DHS'), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.

Method of increasing seed yield and growth eIF-5A

Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1

Regulation of expression of programmed cell death, including senescence, in plants is achieved by integration of a gene or gene fragment encoding senescence-induced deoxyhypusine synthase, senescence-induced elF-5A or both into the plant genome in antisense orientation. Plant genes encoding senescence-induced deoxyhypusine synthase and senescence-induced elF-5A are identified and the nucleotide sequences of each, alone and in combination are used to modify senescence in transgenic plants.

DNA encoding a plant deoxyhypusine synthase, a plant eukaryotic initiation factor 5A, transgenic plants and a method for controlling senescence programmed and cell death in plants

The present invention provides methods for preventing retinal ganglion cell death in the glaucomatous eye and methods for suppressing apoptosis-specific eIF5A1 expression through the use of antisense oligonucleotides targeted to human apoptosis-specific eIF5A1.

Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye

Isoforms of eIF-5A: senescence-induced eLF5A; wounding-induced eIF-4A; growth eIF-5A; and DHS

Growing community of inventors

Waterloo, Canada

John E Thompson