Waters Technologies Corporation

Waters Investments Limited

Boston Scientific Scimed, Inc.

Hydrofera, LLC

John E O'Gara

Kevin Daniel Wyndham

Zhiping Jiang

Raymond P Fisk

Thomas H Walter

Darryl W Brousmiche

Julia Ding

Pamela Carmen Iraneta

Peter Jeng Jong Lee

Sonali Puri

Marianna Kele

Martin Gilar

Ying-Qing Yu

Claude R Mallet

Peter Jeng-Jong Lee

Jennifer Fournier

Eric Lullove

Robert E Richard

Nicole L Lawrence

Daniel P Walsh

Daniel B Walsh

The present invention relates to a compression bandage for treating wounds comprised of a linear elastic compression wrap and a sterilized polymer foam layer containing a plurality of 5 antimicrobial dyes with at least one dye being gram positive and at least one other dye being gram negative and a biofilm reduction agent and wherein said foam is secured to said linear elastic compression wrap.

Antimicrobial bandage

The present invention relates to a compression bandage for treating wounds comprised of a linear elastic compression wrap and a sterilized polymer foam layer containing a plurality of antimicrobial dyes with at least one dye being gram positive and at least one other dye being gram negative and a biofilm reduction agent and wherein said foam is secured to said linear elastic compression wrap.

Antimicrobial compression wrap

The present disclosure provides porous carbon-heteroatom-silicon inorganic/organic homogenous copolymeric hybrid materials, methods for their preparation, and uses thereof, e.g., as chromatographic separations materials. The present disclosure also provides methods of preparing porous inorganic/organic homogenous copolymeric hybrid materials, comprising two or more repeat units, comprising (a) preparing a polyoligomeric siloxane (POS) by partial condensation of tetraalkoxysilane, adding a heterocyclic silane, and further reacting the heterocyclic silane with the POS to thereby prepare a porous inorganic/organic homogenous copolymeric hybrid material, comprising a carbon-heteroatom-silicon functionality or (b) partially condensing an organic olefin, an alkenyl functionalized silane, an alkoxysilane, or a heterocyclic silane, or mixtures thereof, adding a heterocyclic silane, and further reacting the heterocyclic silane with the partially condensed polymer to thereby prepare a porous inorganic/organic homogenous copolymeric hybrid material comprising a carbon-heteroatom-silicon functionality.

Porous carbon-heteroatom-silicon inorganic/organic materials for chromatographic separations and process for the preparation thereof

Porous hybrid inorganic/organic materials comprising ordered domains are disclosed wherein the ordered domains are ordered radially, and having the formula (A)(B)(C)(Formula I) or the formula [A][B](Formula III), wherein A, B, C, x, y and z in Formula I and A, B, x and y in Formula III are further defined herein, and wherein diffraction peak maxima observed for the material exhibit a 2&#x3b8; position that excludes diffraction peaks resulting from atomic-range order that are associated with amorphous material. Methods of making the materials and use of the materials for chromatographic applications are also disclosed.

Porous inorganic/organic hybrid materials with ordered domains for chromatographic separations and processes for their preparation

In accordance with one aspect of the invention, injectable particles are provided which comprise (a) a first group of injectable particles comprising first polymeric particles loaded with a first therapeutic agent and (b) a second group of injectable particles comprising second polymeric particles loaded with a second therapeutic agent. The first and second polymeric particles may be the same or different, and the first and second therapeutic agents may be the same or different. Other aspects of the invention pertain to methods of making such particles, to kits that comprise such particles, and to methods of treatment that employ such injectable particles.

Particles for injection and processes for forming the same

Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, hybrid inorganic/organic monolith materials comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with a surface of a second material are described. The hybrid inorganic/organic materials have enhanced wall adhesion and increased resistance to shrinkage as compared to prior art monolith materials. The improved adhesion of the monoliths enable the preparation of capillary columns with an internal diameter (I.D.) &#x2265;50 &#x3bc;m.

Nanocomposites and their application as monolith columns

The present invention relates to porous inorganic/organic homogenous copolymeric hybrid material materials, including particulates and monoliths, methods for their manufacture, and uses thereof, e.g., as chromatographic separations materials.

Porous inorganic/organic homogenous copolymeric hybrid materials for chromatographic separations and process for the preparation thereof

The present invention provides porous carbon-heteroatom-silicon inorganic/organic homogenous copolymeric hybrid materials, methods for their preparation, and uses thereof, e.g., as chromatographic separations materials.

According to an aspect of the invention, injectable polymeric particles are provided that contain a copolymer that contains a hydroxy-acid-based repeat unit selected from a mono(hydroxy acid) unit and a poly(hydroxy acid) unit, an alkyl-ether-based repeat unit selected from a mono(alkyl ether) unit and a poly(alkyl ether) unit, and an acid-based repeat unit selected from a unit comprising multiple carboxylic acid groups and a derivative thereof. Other aspects of the invention pertain to methods of making such particles. Still other aspects of the invention pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions.

Injectable biodegradable particles

Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, hybrid inorganic/organic monolith materials comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionally capable of chemically interacting with a surface of a second material are described. The hybrid inorganic/organic materials have enhanced wall adhesion and increased resistance to shrinkage as compared to prior art monolith materials. The improved adhesion of the monoliths enable the preparation of capillary columns with an internal diameter (I.D.)&#x2267;50 &#x3bc;m.

Porous hybrid inorganic/organic materials comprising ordered domains are disclosed. Methods of making the materials and use of the materials for chromatographic are also disclosed.

Novel particles and materials for chromatographic separations, processes for preparation and separations devices containing the chromatographic particles and materials are provided by the instant invention. In particular, the invention provides a porous inorganic/organic hybrid particle, wherein the inorganic portion of the hybrid particle is present in an amount ranging from about 0 molar % to not more than about 49 molar %, wherein the pores of the particle are substantially disordered. The invention also provides a porous inorganic/organic hybrid particle, wherein the inorganic portion of the hybrid particle is present in an amount ranging from about 25 molar % to not more than about 50 molar %, wherein the pores of the particle are substantially disordered and wherein the particle has a chromatographically enhancing pore geometry (CEPG). Methods for producing the hybrid particles, separations devices comprising the hybrid particles and kits are also provided.

Porous inorganic/organic hybrid particles having high organic content and enhanced pore geometry for chromatographic separations

Embodiments of the present invention are directed to articles of manufacture, devices, methods and apparatus for performing liquid chromatography featuring a chromatographic sorbent having one or more pentafluorophenyl groups, wherein said one or more pentafluorophenyl groups are a bonded phase on a sorbent selected from the group comprising silica, organic polymers or hybrid organic silane material and said pentafluorophenyl groups are in a mono-, bi-, and tridentate forms.

Method for separating peptides and proteins

Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, the novel materials are porous inorganic/organic hybrid monolith materials, which desirably may be surface modified, and which offer more efficient chromatographic separations than that known in the art.

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Ashland, MA, United States of America

John E O'Gara