E. R. Squibb Sons, Inc.

Bristol-myers Squibb Compnay

John E McCullough

Joseph O'Sullivan

Donald R Kirsch

Adrienne A Tymiak

Janice H Del Mar

Judith Baymiller

CLY4 gene, protein, vectors, and host cells. The gene product pCly4 is involved in fungal cell wall biosynthesis, making it a useful target for anti-fungal agents.

Fungal cell wall Protein CLY4

A novel antibiotic substance, janthinocin, is prepared by cultivation of a strain of the microorganism Janthinobacterium lividum, ATCC No. 53,857.

Gram-positive and gram-negative antibacterial compounds from the

A novel antibiotic substance EM5587 is prepared by cultivation of a strain of the microorganism Lysobacter sp. SC 14,067, A.T.C.C. No. 53042. Chemical analogs of EM5587 are prepared by chemical synthesis.

Antibiotic prepared from lysobacter sp. SC 14,067 and analogs thereof

A method is provided for enhancing penicillin acylase production wherein a Bacillus subtilis plasmid containing an insert of a chromosomal DNA fragment of Bacillus megaterium which includes the appropriate gene for enhancing penicillin acylase production is cloned into Bacillus megaterium and the Bacillus megaterium containing the above plasmid is employed in the production of penicillin acylase. A plasmid method for forming same and host plasmid combination which are useful in the above method are also provided.

Growing community of inventors

Whitehouse Station, NJ, United States of America

John E McCullough