Bristol-myers Squibb Compnay

Bristol-myers Company

John E Leet

Kin S Lam

Koji Tomita

Murray A Kaplan

James A Matson

Wenying Li

Jacqueline M Mattei

Stephen W Mamber

Nicholas A Meanwell

Makonen Belema

Lawrence B Snyder

Michael H Serrano-Wu

Denis R St Laurent

Van N Nguyen

Fukang Yang

Yuping Qiu

Joseph O'Sullivan

Xuejie Yang

Craig R Fairchild

Ramesh Kakarla

Julie A Lemm

Jessica A Gorman

Donald R Gustavson

Daniel M Brown

Donald R O'Boyle, Ii

Xiaohong Liu

Kimberly Brown

Laura Turner

Helen A Ax

King S Lam

Ramesh Kakaria

Donald R Ii O'BOYLE

The present invention relates to xanthone compounds isolated from the plantHochr. (Clusiaceae), a Madagascar plant, which are potent cytotoxic agents.

Cytotoxic xanthone compounds

Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.

Inhibitors of HCV replication

Fermentation of Nocardia sp. ATCC-202099 in the presence of a halogen- or hydroxy-substituted tryptophan precursor yields a novel corresponding halogen- or hydroxy-substituted nocathiacin compound which has broad spectrum antibiotic activity against Gram-positive bacteria and has in vivo efficacy in animals.

Halo- or hydroxy-substituted nocathiacin antibiotics

Novel thiazolyl peptide antibiotic compounds, including nocathiacin I, II and III, are disclosed. Also, novel microorganism ATCC-202099 is disclosed.

Nocathiacin antibiotics

Ascosteroside, obtainable by cultivation of a strain of Ascotricha amphitricha A.T.C.C. No. 74237, analogs thereof and salts and prodrugs of these compounds. The compounds have antifungal activity for use in a method for treating and preventing a fungal infection. Further, the compounds are useful in a method for inhibiting fungal growth.

Ascosteroside and analogs thereof useful in antifungal compositions for

Kedarcidin chromophore, a non-protein chromophore isolated from kedarcidin antitumor antibiotic, is obtained from purified or partially purified kedarcidin by solvent extraction and chromatographic procedures. The chromophore is characterized and found to contain substantially all of the antitumor activity of kedarcidin.

Kedarcidin antitumor chromophore and pharmaceutical composition

A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.

BMY-40800 antitumor antibiotics

Growing community of inventors

Madison, CT, United States of America

John E Leet