Bristol-myers Squibb Compnay

John E Lawson

R Michael Lawrence

Scott A Biller

Richard A Partyka

Henry M Holava

Michael A Poss

Joseph Anthony Tino

Richard B Sulsky

David R Magnin

John K Dickson

John Kenneth Dickson, Jr

Richard E Gregg

John R Wetterau, Ii

Daru Young Sharp

Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.

Inhibitors of microsomal triglyceride transfer protein and method

Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

Nucleic acids encoding microsomal trigyceride transfer protein

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Wallingford, CT, United States of America

John E Lawson