Abbott Laboratories Corporation

Abbvie Inc.

John E Lallaman

Sanjay R Chemburkar

Michael J Abrahamson

Gregory S Wayne

Rajarathnam E Reddy

Julie J Pruyne

Angelica B Kielbus

Anthony Ralph Haight

Howard E Morton

Steven A King

Sou-Jen Chang

Francis A Kerdesky

Arthur J Cooper

Denton C Langridge

Ramiya H Premchandran

Patricia A Oliver

Lakshmi Bhagavatula

Jieh-Heh J Tien

Jonathan P Pease

Francis A J Kerdesky

Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.

Process for the preparation of (S)-2-amino-non-8-enoic acid

Disclosed herein is a process for the preparation of erythromycin derivatives, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.

Process for the preparation of 6-O-propargyl erythromycin derivatives

A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-amino acid derivatives.

Process for the preparation of a disubstituted thiazole

A process for preparing chiral isomers of N-protected 2-azetidinemethanol compounds, particularly N-(phenylmethyl)-2-azetidinemethanol and N-BOC-2-azetidinemethanol, and especially the (R)-isomers thereof, as well as O-substituted derivatives thereof.

Synthesis of chiral 2-azetidinemethanol compounds

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Beach Park, IL, United States of America

John E Lallaman