Hoffmann-la Roche Inc.

John E Heveran

Manfred Weigele

Antonino Focella

Sidney Teitel

Kenneth E Fahrenholtz

Magdalena U Gomez

Harvey Gurien

An improved immunoassay for detecting cannabinoids is described. This immunoassay is characterized by utilizing, as reagents, antibody, .sup.125 I-radiolabeled antigen, an unlabeled antigen and an anion exchange resin for separation of labeled and unlabeled antigen. The iodinated tetrahydrocannabinol moiety is stabilized by the addition of small quantities of antioxidants such as butylated hydroxy toluene.

Radioimmunoassay for cannabinoids

Aminoaryl esters and amino-lower alkyl amides of carboxy substituted barbiturates are linked via an amide linkage to carboxylated latex polymers to form reagents which are useful in a sensitive diagnostic test to detect the presence of barbiturates in body fluids.

Diagnostic test for barbiturates

An improved immunoassay for detecting the drug of abuse phencyclidine is described. This immunoassay is characterized in utilizing as reagents (i) an antibody elicited with a novel immunogen comprising 4-[(1-piperidinyl)cyclohexyl] benzoic acid covalently bonded to an immunogenic carrier material through the carboxyl group and (ii) a novel radiolabeled derivative of phencyclidine, namely .sup.125 I N-(4-hydroxy-2-phenylethyl)-4-[1-(1-piperidinyl)cyclohexyl] benzamide.

Immunoassay for phencyclidine

An improved immunoassay for methadone is disclosed. The subject radioimmunoassay utilizes a novel antigen, antibody and novel labelled methadone derivatives.

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Fairfield, NJ, United States of America

John E Heveran