Battelle Memorial Institute

Battelle Pulmonary Therapeutics, Inc.

Zivena, Inc.

John E Frye

Michael E Placke

Michael J Brooker

William C Zimlich

Michael B Mosholder

Paul T Kotnik

Anthony Rocco Imondi

Douglas R Flanagan

Praful K Shah

Maureen D Donovan

A pulmonary dosing system and method for supplying to a patient a predetermined amount of respirable therapeutically active material. The system comprises a patient interface to introduce the material into the patient's lungs. The patient interface is connected to a flexible inhalation tube and a flexible exhalation tube. The exhalation tube is connected to a filter having an outlet connected to atmosphere. The inhalation tube is connected to an apparatus for providing pulsed amounts of the material entrained in filtered atmospheric air. A control unit operates the pulmonary dosing system in accordance with operator inputs regarding the number of patent exhales between pulses, and pulse length. The exhaust filter and the apparatus for providing pulsed amounts of the therapeutically active material may be enclosed in a containment case and the patient's interface may comprise a mouth tube-mask combination when the therapeutically active material comprises at least one toxic drug.

Pulmonary dosing system and method

A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is a non-encapsulated antineoplastic drug.

Formulation and method for treating neoplasms by inhalation

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Groveport, OH, United States of America

John E Frye