Hyseq, Inc.

Nuvelo, Inc.

Other

John E Ford

George Yeung

Ann Pace

Julio J Mulero

Alice Suk-Yue Ho

Hua Zhou

Dennis G Ballinger

Hai Shan Lin

The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and fetal liver as well as polypeptides encoded by these polynucleotides. The polypeptide is a human chemokine receptor that is a member of a family of G protein-coupled receptors characterized by seven transmembrane domains. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing chemokine receptor polypeptides, and antibodies specific for such polypeptides.

Chemokine receptor obtained from a cDNA library of fetal liver-spleen

Chemokine receptor obtained from a CDNA library of fetal liver-spleen

The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and macrophage as well as polypeptides encoded by these polynucleotides and mutants or variants thereof. The polypeptides correspond to a novel human CD39-like protein. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing novel CD39-like polypeptides, and antibodies specific for such polypeptides.

Methods and materials relating to novel CD39-like polypeptides

The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides of the invention are useful for detecting cancers.

Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein

Method of detecting a cancerous cell expressing an EGF motif polynucleotide

The present invention provides novel nucleic acids, the novel polypeptide sequences encoded by these nucleic acids and uses thereof. These novel polynucleotide and polypeptide sequences were determined to be a novel Interleukin-1 Receptor Antagonist.

Interleukin&mdash;1 receptor antagonist and uses thereof

The present invention provides novel therapeutic methods of administering an amount of IL-1Ra to treat IL-18 related disorders. Specifically, the method involves treating IL-18 related disorders such as liver injury, hepatis, hemophagocytic lymphohistiocytosis, multiple sclerosis, tumors, cytotoxicity resulting from antitumor therapy, or other autoimmune disorders with a therapeutically effective amount of IL-1ra, and optionally measuring IFN-&ggr; and IL-18 activity from human samples.

Therapeutic uses of il-1 receptor antagonist

The invention provides polynucleotides isolated from cDNA libraries of human fetal liver-spleen and macrophage as well as polypeptides encoded by these polynucleotides and mutants or variants thereof. The polypeptides correspond to a human CD39-like protein. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing CD39-like polypeptides, and antibodies specific for such polypeptides.

Methods and materials relating to CD39-like polypeptides

The present invention provides nucleic acids, the polypeptide sequences encoded by these nucleic acids and uses thereof. These polynucleotide and polypeptide sequences were determined to be a Interleukin-1 Receptor Antagonist. Assays for detection of the Interleukin-1 Receptor Antagonist and assays in which the antagonist is used for detection of IL-1 Receptor are also described.

Assays involving an IL-1 receptor antagonist

The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides of the invention comprise amino acid sequences with similarity to EGF-repeat domains.

Antibodies specific for EGF motif proteins

EGF MOTIF protein obtained from a cDNA library of fetal liver-spleen

The present invention provides novel nucleic acids encoding IL-1 Hy2, a novel member of the Interleukin-1 Receptor Antagonist family, the novel polypeptides encoded by these nucleic acids and uses of these and related products.

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San Diego, CA, United States of America

John E Ford