Bristol-myers Squibb Compnay

John E Fairbrother

Stewart A Cederholm-Williams

Derek A Hollingsbee

Ronald S Gardner

Peter A Edwardson

Peter A D Edwardson

Niels Erik Holm

Frank Sebastian Castellana

Allan Garbasch

A novel device and method for applying two or more liquid components, for example fibrin sealant-forming components, comprises sources of the components fliud communication with, but remote from, an applicator for delivering the components to a desired site. Preferably, the user of such a device and method can actuate the application of the components by providing a signal to a controller which dispenses components from their sources to, and out of, the applicator. Greater ease, accuracy and control are realized by the user since the sources of components and controller are remote from the applicator and therefore not manually held by the user.

Method of applying a mixture of two liquid components as well as a device for carrying out the method

Novel fibrin monomer compositions which are solutions including additional coharvested components, such as prothrombin and Factor XIII, are useful in fibrin sealant applications. Preferably, the compositions are autologous to the patient receiving the sealant and these compositions may also include coharvested plasminogen, Factor X, antithrombin III and/or fibronectin.

Compositions useful as fibrin sealants

The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.

Fibrin sealant compositions and methods for utilizing same

Method of making a composition comprising a fibrin monomer

This invention is directed to solid compositions, for example, lyophilized forms, of fibrin monomer. These compositions are useful wherever fibrin monomer could be employed, e.g., as a surgical sealant to provide hemostasis.

Solid compositions of fibrin monomer

The invention relates to fibrin sealants. More specifically, the invention relates to the preparation of a fibrin polymer wherein the polymer is substantially free of the enzyme.

The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin polymer is utilized as a component of the fibrin sealant.

Novel kits for the preparation of a fibrin sealant are disclosed. In one kit a first component is fibrin monomer which can be polymerized to form a fibrin sealant when combined with the second component which is distilled water or an alkaline buffer.

Kit for preparing a fibrin sealant

The present invention relates to a solid support, e.g., a suture, bandage, dressing or prosthesis, and a nondynamic fibrin monomer. The nondynamic fibrin monomer is readily capable of being converted to a fibrin polymer which has sealant and hemostasis properties.

Nondynamic fibrin monomer on bandages, sutures, prostheses and dressings

The subject invention relates to methods and compositions using nondynamic fibrin monomer which is selectively converted to a fibrin polymer which serves as the fibrin sealant.

Methods and compositions using fibrin monomer to make a fibrin sealant

The invention relates to fibrin sealants. More specifically, the invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.

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Clwyd, United Kingdom

John E Fairbrother