Alcon Laboratories, Inc.

Lantheus Medical Imaging, Inc.

Millennium Pharmaceuticals Limited

Carlisle Construction Materials, LLC

Other

Digital Equipment Corporation

Alcon Manufacturing, Ltd.

Alcon Laboraties, Inc.

John E Bishop

Paul W Zinke

Verney L Sallee

Peter G Klimko

Poh K Hui

Eleodoro S Madrigal, Jr

Christoph Koellner

Achim Geiser

I Fraser Pickersgill

Jean-Marc Gomez

Jeff Little

Robert Hett

Mark R Hellberg

Thomas R Dean

Fang-Ting Chiu

Vithalanand R Kulkarni

Young Lo

Stephen Munk

Vince Ammoscato

Louis DeSantis, Jr

Robert D Selliah

George E Barnes

Donald A Carignan

Michael L Chandler

Tom R Dean

V R Boehringer Ingelheim Chem Inc Kulkarni

Eleodoro S Madrigal

Fang-Ting Chui

Fraser I Pickersgill

Louis Desantis Jr

Christoph Amcis Ag Koellner

Fang-Ting Boehringer Ingelheim Chem Inc Chui

Young Boehringer Ingelheim Chemicals Inc Lo

A method of controlling operation of a tire filling mixing machine, by: (a) mixing a rubber/polyurethane and a catalyst in a first mixer to form a virgin polyurethane; (b) grinding cured polyurethane core bits in a grinder; (c) mixing the virgin material and the ground material in a second mixer thereby forming a mixed flatproofing material; (d) injecting the mixed flatproofing material into a tire; (e) measuring the ratio of ground material to virgin material in the mixed flatproofing material; (f) comparing the measured ratio of ground material to virgin material to a pre-stored preferred ratio of ground material to virgin material; and (g) increasing or decreasing the relative percentages of virgin material and ground material entering the second mixer by an amount that is a fraction of the difference between the measured ratio and the pre-stored preferred ratio.

Control system for tire injection filling mixing machine

An auger for a grinder material for a tire filling machine, having: a cylindrical column; and a plurality of flights extending outwardly from the cylindrical core, wherein (i) the flights are arranged in pairs extending radially outwards from the cylindrical column at 180 degrees to one another, and (ii) each flight has a sharpened leading edge. Each pair of flights are positioned at angles of approximately 50 or 60 degrees to one another, and each flight extends approximately half way around the circumference of the cylindrical column, and there are no outer edge notches in the flights.

Auger for grinding polyurethane for a tire filling machine

A method of performing preventative maintenance on an auger in a tire filling mixing machine, by: (a) mixing a polyurethane isocyanate and a catalyst in a first mixer to form a virgin polyurethane; (b) grinding polyurethane core bits in a grinder, the grinder having an auger and a motor; (c) mixing the virgin polyurethane and the ground core bits in a second mixer thereby forming a mixed flatproofing material; (d) injecting the mixed flatproofing material into a tire; (e) measuring vibration of the auger; and (f) comparing the measured vibration of the auger to a predefined maximum vibration; and (g) removing the auger from the grinder if the measured vibration exceeds the pre-defined maximum vibration for a predefined period of time, or removing the auger from the grinder if the measured temperature of the auger exceeds the pre-defined maximum temperature for a predefined period of time.

System for predicting auger failure in a tire injection filling mixing machine

The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

Synthesis of boronic ester and acid compounds

The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.

Preparation of a lipid blend and a phospholipid suspension containing the lipid blend

Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.

Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension

Disclosed is the use of cloprostenol and fluprostenol analogues and combinations thereof with other medicaments for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor. Also disclosed are methods of treating optic nerve disorders using the cloprostenol and fluprostenol analogues.

Growing community of inventors

Groton, MA, United States of America

John E Bishop