Pacific Biosciences of California, Inc.

Talis Biomedical Corporation

Life Technologies Corporation

Other

Mobil Oil Corporation

John Dixon

Thomas Henry Cauley, Iii

Stephen Wilson Turner

Paul M Lundquist

Denis Zaccarin

Yves Lacroix

Sayeed Andeshmand

Michael John McAdams

Hédia Maamar

David Alexander Rolfe

David Glade

Dzam-Si Jesse Ng

Ian Walton

Achim Karger

Robert L Cobene

Alexander V Dukhovny

Dan Kline

Adam Sannicandro

Clarence D Chang

David S Shihabi

Cheng Frank Zhong

Joy Roy

William Robert Hanson

Albert B Schwartz

Ravi Saxena

Michael Simon

Hovig Bayandorian

Alexander Khorlin

Peiqian Zhao

Paul M Newby

Kevin Hester

Bidhan P Chaudhuri

Peng Li

Yanqiao Huang

Yujuan Cheng

Thomas H Iii Cauley

Bin Cao

Kirk Hirano

David Liu

Robert Cobene

Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

Diagnostic system

Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.

Rotary valve

In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

Apparatuses, systems and methods for sequencing using capillary electrophoresis

The present disclosure relates, in some embodiments, to an apparatus for conducting a capillary electrophoresis assay. The apparatus can comprise a capillary array comprising an anode end and a cathode end, the capillary array provided in a housing further comprising a reservoir configured to house a separation medium and an anode buffer. The system can also comprise an injection mechanism configured to deliver sample to the cathode end of the capillary array, and a temperature control zone, wherein the temperature control zone is configured to control the temperature of the interior of the housing.

Capillary array cartridge for capillary electrophoresis systems

The invention provides environmental packages, instruments, and methods for sealing, protecting, and providing analysis chips for processing and analysis. The analysis chips are bonded directly or indirectly to chip carriers which are held within the chambers of an environmental packaging strip. The chambers are sealed with a sealing film such that the chip carriers can be extracted using a piercing tool and an extraction tool.

Sealed chip package

This invention provides systems for analyzing substrates. Also provided by the invention are improved optical systems for enhanced multiplex illumination, optical systems with compact multi-wavelength illumination architectures, optical systems for enhanced detection of optical signals, and optical systems for reduced autofluorescence background noise.

Substrate analysis systems

Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources

Growing community of inventors

Moss Beach, CA, United States of America

John Dixon