Bausch-lomb Incorporated

John Denick

Erning Xia

Zhenze Hu

David J Heiler

Richard V Smerbeck

Lisa C Simpson

Joseph C Salamone

Edward J Ellis

Suzanne F Groemminger

Alyce K Dobie

The use of compositions containing one or more ether amine antimicrobial agents and/or ether amine derivative antimicrobial agents in an amount effective to disinfect and/or preserve medical devices is described. Solutions containing one or more ether amine antimicrobial agent- and/or ether amine derivative antimicrobial agent-containing compositions and methods of making and using the same are also described.

Antimicrobial compositions and uses thereof

The invention provides a method for inhibiting the binding of a biguanide disinfectant in aqueous solution to a poly(ethylene) solid in contact with said solution comprising providing in said solution an amount of cyclodextrin sufficient to inhibit binding of the biguanide disinfectant to the poly(ethylene) solid.

Composition and method for inhibiting uptake of biguanide disinfectants by poly(ethylene)

The present invention is directed to a method of treating dry eye by instilling eyedrops of a composition containing a cationic cellulosic polymer. Such compositions have been found to alleviate the symptoms of dry eye without requiring the presence of anionic therapeutic agents. Low ionic strength solutions are particularly preferred.

Method for treating dry eye

The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone hydrogel lens by plasma treating the lens and subsequently heating the lens in an aqueous solution containing a surface-protective agent.

Surface treatment of silicone hydrogel contact lenses

The present invention provides methods and compositions for cleaning and disinfecting contact lenses, which compositions comprise a carbonate or bicarbonate salt, a non-carbonate buffer system, an antimicrobial agent, and a non-ionic surfactant. Products according to the present invention, especially multi-purpose solutions, provide simultaneous disinfection and cleaning of contact lenses including the prevention or removal of protein and lipid deposits and other debris.

Treatment of contact lenses with aqueous solution comprising a carbonate salt for enhanced cleaning

The present invention is directed to an ophthalmic solution for the treatment of contact lenses while worn in the eye. In particular, the composition contains ethoxylated glucose derivative, tyloxapol, and a polyoxyethylene-polyoxypropylene nonionic surfactant. The ophthalmic solution containing such a combination of components can be applied, in the form of drops, to the eye or to contact lens in the eye. In one embodiment of the invention, the composition is used for reducing unwanted lipid or protein deposition on extended-wear lenses, including lenses made from relatively hydrophobic materials such as silicon hydrogels.

Method and composition for rewetting and preventing deposits on contact

There are disclosed ophthalmic compositions having high water-binding properties which are useful as: moisturizing and lubricating (i.e. artificial tear) solutions, dry eye therapies, contact lens wetting and lubricating solutions, and as delivery vehicles for ophthalmic drugs. The subject compositions include glycerin in combination with propylene glycol. The subject compositions may further include cellulose derivatives, e.g. hydroxypropyl methyl cellulose, along with preservatives, e.g. benzylalkonium chloride, PHMB, sorbic acid, etc. Preferred compositions have at least 11% bound water, a pH from about 7.1 to 7.5, and an osmolality between about 280 to about 320 mOsm/Kg.

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Pittsford, NY, United States of America

John Denick