Packard Instrument Company, Inc.

Abbott Laboratories Corporation

John David Tomisek

John Gordon Rushbrooke

Claire Elizabeth Hooper

Robert W Jaekel

Ronald E Kukla

Russell L Sage

Donald K Jones

Donald E Osten

Shahin Iqbal

Gustaaf C VanCauter

Harry M Young

A method and apparatus of the present invention determines whether zero, one, or a plurality of microscope slide coverslips are about to be applied to a microscope slide. Light, such as ultraviolet light, may be directed toward a coverslip testing region, in which a number of coverslips reside. The amount of light passing through the coverslip testing region is collected and measured. Based on the measured amount, the method and apparatus determine the number of coverslips present in the coverslip testing region.

Method and apparatus for detecting microscope slide coverslips

Method of performing a biomedical assay comprising the steps of exciting the sample or samples with incident radiation of a given wavelength, thereby causing the sample to emit radiation of a different wavelength, measuring the quantity of light falling on a detector receiving the emitted radiation from the sample, thereby to produce a first measurement, illuminating the sample or samples with incident radiation in a manner which does not cause the sample to emit any significant radiation, again detecting the quantity of light falling on the detector, thereby to produce a second measurement and correcting the first measurement, with respect to the second measurement.

Biomedical assays

A system for in-situ measurement of the radioactivity of multiple samples while the samples are in a multiple-well sample tray, with a scintillator in each sample-containing well for producing light pulses in response to radiation from the respective samples. Multiple photomultiplier tubes are positioned adjacent to the sample wells containing the scintillator for simultaneously measuring the radioactivity of multiple samples with only a single photomultiplier tube sensing the scintillations from each well and converting the sensed scintillations into corresponding electrical pulses. The electrical pulses from each photomultiplier tube are processed to discriminate between pulses attributable to sample events within the wells and pulses attributable to non-sample events such as photomultipler tube noise. The discrimination is effected by determining whether a selected number of electrical pulses occurs within a prescribed time interval, the occurrence of the selected number of pulses within the prescribed time interval signifying a sample event. Only the electrical pulses attributable to sample events are supplied to a pulse analyzer.

Scintillation counting system for in-situ measurement of radioactive

Apparatus and a method for determining a quench-indicating parameter of a test sample utilizing a liquid scintillation counter are disclosed. The number of counts in a spectrum resulting from subtraction of a spectrum generated without an external source of radiation from a spectrum generated with an external source of radiation is utilized. The total number of counts is cumulatively summed from a higher energy level to a lower energy level and a curve representing this sum is generated. A portion of this curve is fitted with a function such as a straight line and the intersection of that function with the zero count axis is the intersection energy level which is an indication of the measure of quench of the test sample.

Reverse sum quench measurement using a liquid scintillation counter

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Lombard, IL, United States of America

John David Tomisek