Wayne State University

Radiation Oncology Center Research and Development Corporation

John D Taylor

Kenneth V Honn

Carl R Johnson

James M Onoda

Soan Cheng

Compositions and a method for inhibiting tumor cell induced platelet aggregation are described. Platelet aggregation by tumor cells is part of the metastatic cascade which is interrupted according to the present invention. The compounds include a mixture of at least two members of the group including a calcium channel blocker, a prostacyclin, a thromboxane synthase inhibitor and a phosphodiesterase inhibitor. All of the compounds utilized have an affect on calcium ion which controls platelet aggregation.

Method and compositions for inhibition of tumor cell induced platelet

A method for the treatment of malignant tumors by co-administering a platinum coordination compound and a dihydropyridine class calcium channel blocker compound is described. The compounds are administered over a period of several days in at least two separate dosages of each compound so as to produce regression of the tumor in vitro and in vivo and inhibition of metastasis of the tumor in vivo.

Method and composition for the treatment of tumors by administering a

Novel nitrone substituted 4-aryl dihydropyridines of the formula: ##STR1## are described along with a process for their preparation. The compounds exhibit calcium channel blocker and antimetastatic acitivity.

4-(nitrone aryl) dihydropyridines

The use of calcium channel blocker compounds as antitumor and antimetastatic agents in mammals in vivo and in standard laboratory experimets with tumor cells in vitro is described. In particular the use of nimodipine (Bay e 9736) or nifedipine (Bay a 1040) and structurally related compounds as described.

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Detroit, MI, United States of America

John D Taylor