Alko Ltd.

Other

Orion-yhtyma Oy

John D Sinclair

Risto A Lammintausta

Harry Scheinin

A method for treating eating disorders by repeatedly administering naloxone in a dosage sufficient to block the effects of opiate agonists to a subject suffering from an eating disorder caused by one or more related problem responses; while the amount of naloxone in the subject's body is sufficient to block opiate effects, having the subject make one of the problem responses from which the subject suffers in the presence of stimuli similar to those to which it had been learned, after the amount of naloxone is no longer sufficient to block opiate effects, having the subject make healthy eating responses to food items that do not trigger the problem responses; and continuing the steps of administration of naloxone and having one after another of the problem responses made, followed by having a naloxone-free period in which healthy eating occurs, until the problem responses are extinguished.

Method for treating eating disorders by selective extinction with transdermal naloxone

A method is provided for effectively terminating methadone maintenance therapy and the addiction to other legally-available opiates by selectively extinguishing the opiate-taking responses. Selective extinction is produced having sessions in which detoxified addicts make opiate-taking responses while an opiate antagonist blocks the positive reinforcement, interspersed by periods when the antagonist is absent and all responses except opiate-taking can be emitted. A similar method but with instructions not to take the opiate can subsequently be used to protect against resumption of illegal opiate use, or separately with patients addicted to illegal opiates producing reinforcement through the opioidergic system.

Method for terminating methadone maintenance through extinction of the

A method for treating alcoholism by extinguishing the alcohol-drinking response in which an opiate antagonist is transdermally administered to a subject and a device for transdermally administering the antagonist. The device is a package containing a fixed dose of opiate antagonist, a vehicle and a permeation enhancer.

Method and means for treating alcoholism by extinguishing the

A method for treating alcoholism. The alcohol-drinking response of alcoholics is extinguished by having them drink alcoholic beverages while nalmefene, an opiate antagonist, blocks the positive reinforcement effect of ethanol in the brain.

Method for treating alcoholism with nalmefene

A therapeutic method is provided for use as an adjunct in the treatment of alcoholism. The method consists of extinguishing the alcohol-drinking response of alcoholics during a relatively short period of time by having them drink alcoholic beverage repeatedly while an opiate antagonist blocks the positive reinforcement effects of ethanol in the brain.

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Espoo, Finland

John D Sinclair